By Neus Ferrando Gilabert BSc, MSc (embryologist).
Last Update: 05/05/2014

GnRH analogues are used during ovulation induciton stimulation of ovulation in ICSI and in vitro fertilisation cycles. It is necessary to perform the stimulation of the ovary.
Main advantages of GnRH analogues
The advantages of using this medicine in assisted reproduction cycles are as follows:

  • It reduces the appearance of endogenous luteinizing hormone (LH) peak that would trigger ovulation.
  • It reduces the variability of ovarian response of gonadotropins allowing a synchronised growth of follicles recruited by the ovary.
  • A smaller number of cancelled cycles is achieved.
  • A better scheduling of the cycle by allowing to control the day of ovarian puncture and oocyte insemination.
  • A larger number of oocytes is retrieved after ovarian puncture.
  • A larger number of embryos is obtained after the oocyte insemination and the embryo culture.
  • The likelihood of embryo implantation and gestation increase significantly owing to the effect produced by GnRH analogues on the ovaries and the endometrium at local level.

Authors and contributors

 Neus Ferrando Gilabert
BSc, MSc
Bachelor's Degree in Biology from the University of Valencia (UV). Postgraduate Course in Biotechnology of Human Assisted Reproduction from the Miguel Hernández University of Elche (UMH). Experience managing Embryology and Andrology Labs at Centro Médico Manzanera (Logroño, Spain). More information