The disadvantages of using this medicine for assisted reproduction cycles are as follows:
- Ovarian hyperstimulation syndrome (OHSS).
In artificial insemination, the risk is minimal and may be easily solved by cancelling the insemination cycle.
- Allergic reactions to FSH happen rarely.
- Multiple births.
In artificial insemination, it occurs among 12-30% of cases, being more common among young women with more than 5 ovarian follicles larger than 16 mm and inseminated with more than 30 million spermatozoa.
As for in vitro fertilisation, if two embryos are transferred, the probability of twin pregnancy is 6%. In cycles where three embryos are transferred, the probability of twin pregnancy is 12% and that of triplet pregnancy is 3%.
Medicines containing recombinant FSH present another disadvantage: they are more expensive because bioengineering should be used for the production of recombinant FSH.
Medicines containing recombinant FSH which are usually prescribed for assisted reproductive treatments are Gonal and Puregon.