Disadvantages of GnRH analogues

GnRH analogues are used during ovulation induction in ICSI, in vitro fertilisation, PGD or assisted hatching cycles.

Main disadvantages

The disadvantages of using this medicine in assisted reproduction cycles are as follows:

  • It causes insufficiency of corpus luteum, this is why progesterone should be prescribed to the patient during the luteal phase (third and the last stage of menstrual cycle).
  • The incidence of Ovarian Hyperstimulation Syndrome increases owing to flare-up effect of GnRH analogues.
  • There is a higher risk of multiple pregnancy due to embryos placed in the mother’s womb are more likely to implant during embryo transfer.
  • Appearance of follicular cysts: it has an incidence of 14-29%. This large difference is due to they are more frequent when the short protocol of ovulation induction is used, it is suggested that they arise as a result of flare-up effect.
  • It may cause headaches and/or paraesthesias: incidence is lower than 6%.
  • The reappearance of the pituitary function and, therefore, menstrual cycle of the woman is not immediate after the treatment, this is why it is delayed.

It is recommended to read the possible side effects of GnRH analogue that your doctor has prescribed to you (Decapeptyl or Synarel).

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