Effects of GnRH analogues

GnRH analogues are a medicine used in assisted reproduction treatments. They are specifically employed in the ovarian stimulation of the woman.

This medicine acts by stimulating the ovary in order that more eggs develop in the same cycle.

The effects of GnRH analogues are as follows:

  • The initial release of gonadotropins, above all FSH and LH, is also known as flare-up effect.
  • The pituitary gland blocks the release of gonadotropins when the FSH and LH reserve empties, avoiding communication between the pituitary gland and the ovary in order that the pituitary gland does not influence ovulation. It occurs between 5-10 days after the first administration.

Effects on assisted reproduction

This involves to synchronise the cohort of follicles recruited by the ovary, allowing an homogeneous follicular growth and reducing the variability of the ovarian response to gonadotropin hormones, which are administered exogenously.

This is a beneficial effect because it allows the doctor monitoring the patient to know when is the best time to trigger ovulation and to schedule the ovarian puncture or follicular puncture.

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