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What may be the cause of Sertoli syndrome?

By Paloma de la Fuente Vaquero M.D., Ph.D., M.Sc. (gynecologist).
Last Update: 03/08/2022

Sertoli syndrome (germinal aplasia) consists of a testicular alteration characterized by not finding spermatogonia or spermatozoa (germ cells) at the level of the seminiferous tubule, only Sertoli cells (those whose mission is to provide structural and metabolic support to germ cells or future sperm cells). It is a cause of permanent and irreversible sterility. Since there are no spermatozoa in the testicle, it is not possible to resort to any assisted reproduction technique with the patient's own sperm, thus requiring donor sperm.

Among the fundamental causes of germinal aplasia (Sertoli syndrome), there are congenital or acquired causes: poor testicular descent, radiation, cytostatic drugs.

 Paloma de la Fuente Vaquero
Paloma de la Fuente Vaquero
M.D., Ph.D., M.Sc.
Gynecologist
Bachelor's Degree in Medicine from the Complutense University of Madrid, with a Master's Degree in Human Reproduction and a Doctorate in Medicine and Surgery from the University of Seville. Member of the Spanish Fertility Society (SEF) and the Spanish Society of Gynecology and Obstetrics (SEGO), she performs as a gynecologist specializing in assisted reproduction in the clinic IVI Sevilla.
License: 4117294
Gynecologist. Bachelor's Degree in Medicine from the Complutense University of Madrid, with a Master's Degree in Human Reproduction and a Doctorate in Medicine and Surgery from the University of Seville. Member of the Spanish Fertility Society (SEF) and the Spanish Society of Gynecology and Obstetrics (SEGO), she performs as a gynecologist specializing in assisted reproduction in the clinic IVI Sevilla. License: 4117294.