By Cristina Mestre Ferrer BSc, MSc (embryologist).
Last Update: 03/20/2015

Evopad is a drug used in assisted reproduction. They are adhesive patches, which are applied directly to the skin. The patches contain estrogen, which is used during estrogen replacement therapies before the transfer of frozen or donated eggs.

Before using the patches, the information leaflet should be carefully read and the doctor’s instructions should be followed.


Evopad is composed of estradiol, a female sexual hormone. Each box contains 8 transdermal and adhesive patches. These patches are square-shaped and transparent and have a thickness of 0.1 millimetres. They are kept inside protective bags, which are hermetically sealed and should be directly applied to the skin.

Estrogen patches

There are four available presentations and four different sizes and doses:

  • Evopad 25: its surface measures 8 cm² and it contains 1.6 mg of hemihydrate estradiol. This corresponds to an estradiol release of 25 micrograms every 24 hours.
  • Evopad 50: it has a 16 cm² surface and contains 3.2mg of hemihydrate estradiol. 50 micrograms are released every 24 hours.
  • Evopad 75: it has a surface of 24 cm² and contains 4.8mg of hemihydrate estradiol. 75 micrograms are released every 24 hours.
  • Evopad 100: its surface measures 32 cm² and it contains 6.4mg mg of hemihydrate estradiol. 100 estradiol micrograms are released every 24 hours.

Instructions for use

If Evopad is used to prepare the endometrium for an assisted reproduction treatment, the estrogenic dose should be completed with progesterone.

The patch is directly applied on clean and dry skin, in a zone under the waist. Lotions and creams, which may alter the patches adhesive properties should not be used. The application zone shouldn’t always be the same. The patient should wait at least one week before applying the patch to the same area.

Evopad should be used immediately after opening the package. After discarding the protective foil, you should apply the patch to the chosen area, starting from the edges to the centre, avoiding the creation of wrinkles. Remove the second protective layer and apply the newly uncovered part. With the palm of your hand, put some pressure on the patch so it can properly adhere to your skin. Try to avoid touching the adhesive part with your fingertips during application.


Evopad should not be administered in the following cases:

  • If you have, had, or think you are having breast cancer.
  • If you have allergy or hypersensitivity to any active substance or excipients.
  • If you have estrogen-dependent tumours.
  • If you have vaginal bleeding of unknown origin.
  • If you have known thrombophilic alterations.
  • If you have acute kidney or liver disorders.

Adverse reactions to Evopad

If, during the use of this medicine, you have vaginal bleeding, chest pain or any other symptoms you should contact your doctor immediately.

Adverse reactions

The most common side effects occur in at least 10% of cases. These side effects are: headaches, breast tension, and allergic reactions in the area where the patches were applied.

Common reactions happen in between 10% and 1% of cases. These symptoms are: insomnia, heart palpitations, nervousness, breast growth, irregular vaginal bleeding, uterine spasms, back pain, and breast cancer.

The less common reactions (1%-0.1%) are: vertigo, nausea, abdominal pain, diarrhoea, high blood pressure, and migraines.

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Authors and contributors

 Cristina Mestre Ferrer
BSc, MSc
Bachelor's Degree in Biological Sciences, Genetics & Human Reproduction from the University of Valencia (UV). Master's Degree in Biotechnology of Human Assisted Reproduction from the UV and the Valencian Infertility Institute (IVI). Embryologist at IVI Barcelona. More information