GnRH antagonists are used during ovulation induction in cycles of in vitro fertilisation, ICSI, PGD, or assisted hatching. This allows the production of a greater number of follicles, which in turn would allow a larger number of eggs to be obtained after follicular puncture so that the treatment can be performed.
Its established indications are:
- Women over age 37.
- Poor-responders: women who presented a low response to ovarian stimulation (i.e. the number of ripe follicles) in previous assisted reproduction cycles and, therefore, the number of eggs obtained after egg retrieval was too low.
- Women at increased risk of ovarian hyperstimulation syndrome (OHSS).
- Where the immediate cancellation of endogenous gonadotropins (FSH and LH) production is required.