Kallmann Syndrome (KS) is associated with hypogonadotropic hypogonadism (HH), hence that it is sometimes abbreviated with the acronym KS-HH. In people who suffer from KS, the functions of the hypothalamus and/or hypophysis is altered.
As a result, the affected person lacks both male and female sex hormones, which will limit his or her sexual development. These patients do not develop the secondary sexual characteristics typically developed during puberty if they are not treated with a hormonal replacement therapy. Additionally, it is likely that they are infertile.