Multiple Pregnancy and Assisted Reproduction

By MD, MSc (gynecologist), MD, PhD (gynecologist) and BSc, MSc (embryologist).
Last Update: 01/03/2019

Multiple births are associated with Assisted Reproductive Technology (ART) to a large extend.

In the last decade, the cases of women who have given birth to twins or even triplets have increased, which has led infertility specialists to establish a series of guidelines to prevent this, since multiple pregnancies entail more risks than singleton pregnancies.

Being pregnant with more than one embryo can lead to severe complications for both the health of the mother and the babies. For these reasons, carefully evaluating the pros and cons before making a decision as regards the number of embryos to transfer.

Fraternal vs. identical twins in ART

Multiple pregnancies achieved following assisted conception result in fraternal twins and not in identical twins, since they are the result of two eggs that have been fertilized using two different sperms.

This occurs because ovarian stimulation, both in Intrauterine Insemination (IUI) or In Vitro Fertilization (IVF) cycles, triggers the maturation of multiple follicles, each one containing a different egg.

The chances of getting pregnant with twins are higher in IVF cycles where multiple embryos are transferred. For this reason, the general recommendation is to transfer a single embryo in all cases. Nonetheless, in certain cases such as women of advanced maternal age, the specialist may consider transferring two or more embryos.

Based on the data generated by all clinics providing ART services, the American Society for Reproductive Medicine (ASRM) and the Society for Assisted Reproductive Technology (SART) have defined a series of guidelines to follow when it comes to deciding the number of embryos to transfer:

Patients under the age of 35 should be encouraged to receive a single-embryo transfer, regardless of the embryo stage. For patients between 38 and 40 years of age, no more than three cleavage-stage embryos or two blastocysts should be transferred. Patients 41–42 years of age should plan to receive no more than four cleavage-stage embryos or three blastocysts.

In Intrauterine Insemination (IUI) cycles, mild ovarian stimulation is performed in order to trigger the development of a maximum of one or two follicles, so that finally only one egg is fertilized. In case multiple follicles develop, the cycle should be cancelled to avoid a multiple pregnancy.

One should not forget that a twin pregnancy can occur naturally, even if pregnancy is achieved through ART. The embryo can split into two after insemination or IVF embryo transfer, resulting in identical twins.

Seeking IVF to have twins

Nowadays, reproductive endocrinologists and & infertility specialists insist on the importance of elective single embryo transfers (eSETs) to prevent a multiple pregnancy. However, many patients disagree with this.

Most intended parents do not want to stack everything on a single embryo. In fact, they prefer to have fraternal twins from a single cycle in order not to go through another cycle in the future to have more children.

If you need to undergo IVF to become a mother, we recommend that you generate your Fertility Report now. In 3 simple steps, it will show you a list of clinics that fit your preferences and meet our strict quality criteria. Moreover, you will receive a report via email with useful tips to visit a fertility clinic for the first time.

Fertility treatments are hard to cope with emotionally. Several regular visits to the clinic, along with the expensive cost of fertility treatments per cycle, make them inaccessible for many families.

The following are the main pros and cons of getting pregnant with multiples following ART:

Pros of multiple pregnancies

As we have explained above, the main advantage of a multiple pregnancy following ART is that the couple does not need to start a cycle anew. With the birth of two babies at the same time, they fulfill their dream of becoming parents and stop seeking a new pregnancy.

Another advantage is that, when pregnant with twins, the intended mother goes through pregnancy and childbirth only once, experiences that only few women are willing to repeat over their lifetime.

Finally, we should mention the special bond that develops between twins. They grow up together, learning to share everything with each other, and become excellent playmates.

Cons of multiple pregnancies

The main cons of multiple pregnancies are due to the risks it conveys for both the mother and the babies, including:

Preterm birth
When delivery occurs before week 37 of pregnancy.
Placenta previa
When the placenta attaches near to the cervix, covering it totally or partially.
Preeclampsia
A type of high blood pressure that occurs during pregnancy. It causes kidney problems, causing the loss of proteins through urine.
Gestational diabetes
A type of diabetes that appears for the first time when the woman gets pregnant. It typically appears after the first trimester.
C-section birth
A surgical incision is performed on the abdomen and the uterus to deliver the babies.
Postpartum bleeding
It is considered bleeding if the loss excess more than 500 ml of blood after a vaginal birth, or over 1,000 after a C-section.
Miscarriage or vanishing twin syndrome
Although most twin pregnancies develop without problems, the risk of miscarriage is higher than in singleton pregnancies.
Twin-to-twin transfusion syndrome
A pregnancy complication that occurs when the fetuses share the same placenta, since blood is transferred between one another. A blood deficiency can occur in one of them, with the subsequent excess for the other.
Intrauterine growth restriction
The fetus is unable to grow as much as he needs due to a deficiency of nutrients and/or oxygen. Usually, it is due to complications in the placenta.
Low birth weight
It is diagnosed when the weight is below 2.5 grams.
Perinatal mortality
Perinatal death occurs when the fetus dies at week 28 of pregnancy or later, or within the first seven days after being born.
Chromosomal abnormalities
It is estimated that multiple pregnancies carry two times the risks of developing chromosomal abnormalities than singleton pregnancies, especially if the mother is 35 years old or more.

Furthermore, if the intended mother is older than 38, a multiple pregnancy can increase the risk for other complications, including thrombophilia or cardiac arrest. For this reason, if a multiple occurs from ART, sometimes doing a selective reduction is necessary in case 2 or more embryos have implanted.

On the other hand, once the babies are born, complications may arise at home. A greater volume of tasks to do, sleepless nights, money, etc. is required as the number of children increases. Twin children require their parents’ full attention, and sometimes even extra help is necessary.

FAQs from users

Is a preterm birth more likely with twins?

By Manuel Aparicio Caballero MD, MSc (gynecologist).

According to the World Health Organization (WHO), a preterm birth occurs when the child is born before the week 37 of pregnancy. Some of the most common causes of preterm birth are:

  • Overdistention of the uterus: loss of tone in the uterine musculature that prevents this organ to recover its normal size.
  • Infection or uterine inflammation: certain bacteria can damage fetal membranes by causing its rupture and triggering a preterm birth. An infection that affects the uterus directly may lead to preterm birth as well.
  • Decidual bleeding: a type of vaginal bleeding that may occur while a woman is pregnant.

There exist many risk factors that can lead to premature birth, including obesity, high blood pressure, etc. A multiple pregnancy is one of these factors.

How can multiple pregnancy from assisted reproductive technology be prevented?

By Manuel Fernández MD, PhD (gynecologist).

There are lots of actions to be taken, most of them being implemented with increasing success.

As for in vitro fertilisation, a three-embryo transfer should be avoided: cases with a good prognosis should bet on a single embryo transfer instead. This requires a process of raising awareness not only by the couple undergoing the treatment but also by the professional team.

The “success” of an assisted reproductive treatment does not consist only on achieving pregnancy. More and more, we need to be aware that the ultimate aim should be having a healthy baby, that is to say, that the child is not born too early.

Despite changing this mindset may be difficult, we insist on the need to prevent multiple births.

I want to have twins. Can I make this decision in my IVF cycle?

By Zaira Salvador BSc, MSc (embryologist).

Yes, it is possible for a woman or couple to decide to transfer two or more embryos instead of just one. However, you should follow strictly the recommendations of specialists and prevent the risks a multiple pregnancy entails. Moreover, not all embryos transferred are always able to attach to the uterus.

Can you get pregnant with twins after using donor eggs?

By Zaira Salvador BSc, MSc (embryologist).

Yes, although it depends on the number of embryos transferred. Moreover, the pregnancy success rates with donor eggs are higher than with own eggs, given that donor eggs have an excellent quality.

Suggested for you

To get more info about the things to keep in mind when it comes to deciding how many embryos to transfer in an IVF cycle, click here: How Many Embryos Should You Transfer for IVF?

A multiple pregnancy entails several risks, especially in women of an advanced maternal age. Want to learn more about this? Read: Potential Complications of Multiple Pregnancies.

Our editors have made great efforts to create this content for you. By sharing this post, you are helping us to keep ourselves motivated to work even harder.

References

ASRM American Society for Reproductive Medicine. Challenges of Parenting Multiples. Patient’s Fact Sheet. Birmingham, Alabama 35216-2809.

Barri, P. (1996) Are multiple pregnancies an inevitable consequence of AMP techniques? In Press.

Craandjik, M., Helmerhorst, F.H., Koudstaal, J. et al, (1996) The influence of assisted procreation on the perinatal outcome of twin pregnancies. [Abstr. no. 859] Hum. Reprod., 11 (Abstr. Book 1), 40.

Fahri, J. (1996) Treatment of anovulatory infertility: the problem of multiple pregnancies. Hum. Reprod., 11, 429-34

Filicori, M., Cognigni, G.E., Arnone, R. et al. (1996) Is multiple pregnancy an unavoidable complication of ovulation induction? The case for pulsatile GnRH. Eur. J. Obstet. Gynecol., 65 (Suppl. 1), 519-521.

Kovacs P: Multiple pregnancies after ART and how to minimize their occurrence. Current Women’s Health Reviews 2012, 8(4):289–296.

Nijs, M. and Geerst, L. (1993) Prevention of multiple pregnancies in an IVF program. Fertil. Steril., 59, 1245-1250.

Nylander, P.P.S. (1981) The factors that influence twinning rates. Acta Genet. Med. Gemellol., 30, 189–202.

Olivennes, M, Kadheo, P., Rufat, P. et al. (1996) Perinatal outcome of twins pregnancies after IVF. Fertil. Steril, 66, 105-109.

Penzias, Alan et al. (2017). Guidance on the limits to the number of embryos to transfer: a committee opinion. Fertility and Sterility, Volume 107, Issue 4, 901-903.

Senoz, S., Benchetrit, A. and Casper, R. (1997) An IVF fallacy multiple pregnancy risk is lower for older women. /. Assist. Reprod. Genet., 14, 192-198.

Staessen, C. and Camus, M. (1992) The relationship between embryo quality and the occurrence of multiple pregnancy. Fertil. Steril, 57, 626-630.

Vilska S, Tiitinen A, Hyden-Granskog C, Hovatta O. Elective transfer of one embryo results in an acceptable pregnancy rate and eliminates the risk of multiple births. Hum Reprod 1999;14:2392– 2395

FAQs from users: 'Is a preterm birth more likely with twins?', 'How can multiple pregnancy from assisted reproductive technology be prevented?', 'I want to have twins. Can I make this decision in my IVF cycle?' y 'Can you get pregnant with twins after using donor eggs?'.

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Authors and contributors

 Manuel Aparicio Caballero
Manuel Aparicio Caballero
MD, MSc
Gynecologist
Bachelor's Degree in Medicine from the University of Murcia. Specialist in Obstetrics & Gynecology. Master's Degree in Human Reproduction from the King Juan Carlos University and the IVI. Currently, he is part of the team of Tahe Fertilidad (Murcia, Spain). More information about Manuel Aparicio Caballero
License: 303008030
 Manuel Fernández
Manuel Fernández
MD, PhD
Gynecologist
Graduate in Medicine and Surgery from the University of Seville. Specialist in Obstetrics and Gynecology from the University Hospital Virgen Macarena de Seville. Master's Degree in Assisted Reproduction from the Rey Juan Carlos University of Madrid. Gynecologist at IVI Seville since 2003 and Director since 2005. More information about Manuel Fernández
License: 4114231
 Zaira Salvador
Zaira Salvador
BSc, MSc
Embryologist
Bachelor's Degree in Biotechnology from the Technical University of Valencia (UPV). Biotechnology Degree from the National University of Ireland en Galway (NUIG) and embryologist specializing in Assisted Reproduction, with a Master's Degree in Biotechnology of Human Reproduction from the University of Valencia (UV) and the Valencian Infertility Institute (IVI) More information about Zaira Salvador
License: 3185-CV

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