Success Rates in Assisted Reproduction

By BSc, MSc (embryologist) and BA, MA (fertility counselor).
Last Update: 12/22/2014

The different assisted reproduction techniques have different success rates, i.e. an uneven possibility of achieving pregnancy. One of the factors that have the most influence is the age of the woman, which means most of the clinics present an unlike success rate in the different age ranges.

Success rate with artificial insemination

Insemination with partner’s sperm

Artificial insemination (AI) is not recommended for women older than 37, due to its ineffectiveness.

  • Women younger than 35 years: 17-23% pregnancy rate
  • Women between 35 and 40 years: 15-21% pregnancy rate
  • Women older than 40: 13% pregnancy rate

Furthermore, it’s been proved that the possibilities of achieving pregnancy increase, if more than one cycle is performed. That’s why it’s said that artificial insemination has a cumulative success rate.

  • One cycle: 15-23% pregnancy rate
  • Two cycles: 26-34% pregnancy rate
  • Three cycles: 35-42% pregnancy rate
  • Four cycles: 40-60% pregnancy rate

Artificial insemination with donors sperm (AID)

When donor’s sperm is used, the likelihood of achieving pregnancy increases slightly, since donors must have an exceptional seminal quality to be accepted.

  • Women younger than 35 years: 17-33% pregnancy rate
  • Women between 35 and 40 years: 17-29% pregnancy rate
  • Women older than 40: 16% pregnancy rate

The cumulative success rate of the artificial insemination with donor is:

  • One cycle: 17-28% pregnancy rate
  • Two cycles: 30-46% pregnancy rate
  • Three cycles: 48-60% pregnancy rate
  • Four cycles: 60-75% pregnancy rate

Pregnancy rate with IVF

IVF is a technique with higher intervention of the specialist. It’s recommended for the most severe fertility alterations, or when there have been repeated failures with artificial insemination. Donor’s eggs and sperm can be used if needed.

IVF with eggs and sperm of the couple

  • Women younger than 35 years: 30-60% pregnancy rate
  • Women between 35 and 40 years: 27-40% pregnancy rate
  • Women older than 40: 30% pregnancy rate

IVF with egg donation and sperm of the couple

  • Women younger than 35 years: 55-63% pregnancy rate
  • Women between 35 and 40 years: 55-60% pregnancy rate
  • Women older than 40: 55-60% pregnancy rate

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References

Sociedad Española de Fertilidad. Registro Nacional de Actividad 2014-Registro SEF (https://www.sefertilidad.net/)

Abuzeid MI, Bolonduro O, La Chance J, Abozaid T, Urich M, Ullah K, Ali T, Ashraf M and Khan I. Cumulative live birth rate and assisted reproduction: impact of female age and transfer day. Facts Views Vis Obgyn. 2014; 6(3):145-149.

Devesa M, Tur R, Rodríguez I, Coroleu B, Martínez F, Polyzos NP. Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women ≥38 years old. Hum Reprod. 2018;33(11):2010-2017.

Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med. 2009 Jan 15;360(3):236-43.

Roque M, Valle M, Guimarães F, Sampaio M, Geber S. Freeze-all policy: fresh vs. frozen-thawed embryo transfer. Fertility and Sterility, 2015;103:1190-1193.

Zhu Q, Chen Q, Wang L, Lu X, Lyu Q, Wang Y, Kuang Y. Live birth rates in the first complete IVF cycle among 20 687 women using a freeze-all strategy. Hum Reprod. 2018 May 1;33(5):924-929.

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Authors and contributors

 Cristina Mestre Ferrer
Cristina Mestre Ferrer
BSc, MSc
Embryologist
Bachelor's Degree in Biological Sciences, Genetics & Human Reproduction from the University of Valencia (UV). Master's Degree in Biotechnology of Human Assisted Reproduction from the UV and the Valencian Infertility Institute (IVI). Embryologist at IVI Barcelona. More information about Cristina Mestre Ferrer
Adapted into english by:
 Sandra Fernández
Sandra Fernández
BA, MA
Fertility Counselor
Bachelor of Arts in Translation and Interpreting (English, Spanish, Catalan, German) from the University of Valencia (UV) and Heriot-Watt University, Riccarton Campus (Edinburgh, UK). Postgraduate Course in Legal Translation from the University of Valencia. Specialist in Medical Translation, with several years of experience in the field of Assisted Reproduction. More information about Sandra Fernández

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