By Neus Ferrando Gilabert BSc, MSc (embryologist).
Last Update: 04/15/2014

Utrogestan stands for a drug used in Assisted Reproductive Technology (ART) to achieve a greater endometrium thickness, favoring embryo implantation into the uterus.

Reading carefully the instructions before using this drug is essential.

The different sections of this article have been assembled into the following table of contents.

Composition

It is composed by female sex hormones and its main active substance is progesterone. It is also composed by peanut oil, soy lecithin, gelatin, glycerin, and titanium dioxide (E171).

It is a thyroid hormone that participates in the woman’s ovarian cycle. Furthermore, it assures that the uterus is in perfect condition to receive the fertilized egg.

This hormone also can regulate an irregular cycle or a cycle with heavy bleeding.

These drugs have several forms:

  • Pack of 15 capsules of 200 mg active ingredient: Utrogestan 200mg
  • Pack of 30 capsules of 100 mg progesterone: Utrogestan 100mg

Instructions for use

Any treatment with Utrogestan must be monitored very closely, trying to personalize the doses and the length of the treatment for each patient to the maximum. The recommended dose depends on the blood hormone levels.

Utrogestan is usually prescribed for a period from 12 to 14 days.

When the treatment with porgesterone begins, a slight bleeding may occur. It is important not to confuse this bleeding with the bleeding produced during menstruation because this is a lighter, shorter, less painful one.

If Utrogestan is orally administered, the average recommended dose ranges from 200 to 300 milgrams (mg) per day, typically 200 mg at bedtime, or 100 mg in the morning and 200 mg at bedtime.

It is recommended to be taken everyday at the same time and en an empty stomach since the intake of food increases the absorption of the drug.

Where the drug is vaginally admnistered, the average recommended dose ranges from 100 mg to 600 mg per day. Capsules, also called eggs, must be introduced in the vagina and pushed with the fingers.

In case you forget to take an Utrogestan once during the treatment, it is important not to take a double dose to make up the missed one.

Contraindications

Utrogestan should not be taken in any of the following cases:

  • Allergy to progesterone.
  • Suffering from thromboembolism.
  • Enduring vaginal bleeding.
  • Suffering from hepatic problems.

As this drug may cause somnolence, special attention should be given when driving or using heavy machines. For this reason, it is recommended to take the dose at night, that is, before sleeping.

Progesterone is passed in breast milk. For this reason, it is not recommended to take it while breastfeeding. Regarding pregnancy, since progesterone is an hormone that increases its levels during pregnancy, its administration during a gestation may have no side effects.

Side effects

The most common side effects of Utrogestan are:

  • Shortened menstrual cycle
  • Spotting
  • Amenorrhea (missing a monthly menstrual period)
  • Somnolence and deep sleep
  • Dizziness, feeling of vertigo

If you notice any other symptoms or reactions, you will need to go to a doctor right away.

Utrogestan does not need to be kept in special conditions. It is important to keep it out of the reach of children.

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Authors and contributors

 Neus Ferrando Gilabert
BSc, MSc
Embryologist
Bachelor's Degree in Biology from the University of Valencia (UV). Postgraduate Course in Biotechnology of Human Assisted Reproduction from the Miguel Hernández University of Elche (UMH). Experience managing Embryology and Andrology Labs at Centro Médico Manzanera (Logroño, Spain). More information
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