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How successful is intrauterine insemination (IUI) with donor sperm?

By Michelle Lorraine Embleton B.Sc. Ph.D. (biochemist).
Last Update: 05/27/2024

Michelle Emblenton, a biochemist at inviTRA, tells us about the success rate of artificial insemination with donor sperm:

Intrauterine insemination with donor sperm generally has greater success rates than the same treatment using partner sperm, and this is because donor sperm is of exceptional quality and comes from young fit healthy men. However, one of the most important factors to consider when looking at the success of this treatment is actually the age of the recipient woman, as the age of the woman usually will determine the quality and quantity of her eggs. To have a look at the statistics of success, I have available the Spanish Fertility Society's data from 2020. In this data we can see that, for women under the age of 35, the success rate in terms of delivery of healthy baby is approximately 17.8% when performed with donor sperm and 10.9% when performed with partners sperm. When the age range of the recipient woman is between 35 and 39, the birth rate is 13.3% when using donor sperm and 8 .9% when using partners sperm. When women are over 40 years old, the treatment is generally less successful, with a success birth rate of 5.8% for using donor sperm and 4% for using partner sperm. The success rate when performing an intrauterine insemination is cumulative, meaning that the more attempts you try the more likely you are to get pregnant. For this reason, if it doesn't work the first time, you will be encouraged to repeat the process maybe up to four times. In the case of single women or same-sex female couples where there are no fertility issues, you may be suggested to try the treatment up to six times.

 Michelle Lorraine Embleton
Michelle Lorraine Embleton
B.Sc. Ph.D.
Biochemist
PhD in Biochemistry, University of Bristol, UK, specialising in DNA : protein intereactions. BSc honours degree in Molecular Biology, Univerisity of Bristol. Translation and editing of scientific and medical literature.
Biochemist. PhD in Biochemistry, University of Bristol, UK, specialising in DNA : protein intereactions. BSc honours degree in Molecular Biology, Univerisity of Bristol. Translation and editing of scientific and medical literature.