Today, advances in medicine make it possible to address solutions so that men and women can fulfill their desire to have children at the right time.
Fertility preservation consists of collecting and freezing eggs and sperm in straws or other freezing methods, and keeping them immersed in liquid nitrogen for an unlimited time. Thus, these cells can be kept intact until the moment when one wishes to have offspring and can be used in an assisted reproduction treatment with high success rates.
Freezing ovarian and testicular tissue is an alternative to egg and sperm cryopreservation. However, the safety and effectiveness of these methods have not been proven yet.
Provided bellow is an index with the 8 points we are going to expand on in this article.
When do you need to preserve your fertility?
Mainly, there are two specific cases in which it is recommended to preserve ones fertility:
- Cancer patients: Chemotherapy and radiotherapy treatments are very aggressive and can attack the precursor cells of eggs and sperm. In these cases, the gametes can be frozen to avoid having to resort to egg and/or sperm donors in the future.
- delaying motherhood: a woman is born with a finite number of eggs, which diminishes over time. In addition, not only is the quantity of eggs reduced, but also their quality.
Dr. Irene Romero, specialist in Gynecology and Obstetrics, comments that:
Today we like to talk about the preservation of fertility as an opportunity. An opportunity for patients to be their own donors in case they need to undergo egg donation.
Fertility preservation for women
Today, the number of women who choose to preserve their fertility has grown considerably. The main cause of this increase has been the increasingly marked tendency to delay motherhood, either because of lifestyle reasons or because of the socio-economic situation in which we live.
Other reasons why many women decide to preserve their fertility is because they are going to undergo cancer treatment or because they suffer from diseases that affect the ovarian reserve, such as endometriosis.
The following are the different alternatives that women have to preserve their reproductive function.
Egg vitrification is a fertility treatment that consists of the ultra-fast cryopreservation of eggs at low temperatures. The eggs are stored frozen in liquid nitrogen tanks called egg banksfor an unlimited time without losing its physical and functional characteristics.
Therefore, the main advantage of oocyte vitrification is that it maintains the quality of the oocytes at all times until the woman decides to use them.
To be able to vitrify oocytes it is necessary for the woman to administer the hormonal medication that will cause several oocytes to mature at once, and thus be able to aspirate them directly from the ovary by means of follicular puncture.
The eggs obtained are then frozen using the vitrification method and stored in the egg bank indefinitely. When a woman wants to become a mother, she will have to resort to in vitro fertilization (IVF) with her frozen eggs.
If you would like more information about this technique to preserve female fertility, you can read on in the following article: What is egg vitrification and what are its advantages?
An alternative to egg vitrification offered to heterosexual couples is to freeze the fertilized eggs, when they have already begun to divide, i.e. to freeze the embryos.
The process of freezing embryos is similar to that of vitrification of eggs. The embryos are placed in a cryoprotective medium and placed in vitrification straws. The straws are then stored in an embryo bank, where they remain frozen in liquid nitrogen until they are used.
If you are interested in learning more about this particular technique, you can get more details here: What is embryo vitrification - when and how is it done.
Ovarian transposition, also known as ovariopexy, is a method of preserving female fertility that prevents possible injury to the gonads in the event of cancer.
This technique consists of moving the ovaries to another part of the body, with the aim of moving them away from the place where the radiotherapy is to be performed. Once the cancer treatment has been completed, the ovaries are returned to their original position.
Freezing of ovarian tissue
Freezing ovarian tissue is an experimental technique, so it has not yet been carried out. This method of preservation would be recommended for pre-pubertal girls diagnosed with cancer.
The procedure for freezing ovarian tissue involves a biopsy to remove small pieces of the crust of the woman's ovaries, where the eggs develop as adults. It should be noted that the cortex of the ovaries of prepubertal girls contains the egg precursor cells.
The extracted immature tissue is dissected into thin sheets and frozen in liquid nitrogen. Later, once the cancer is confirmed to be gone and adulthood is reached, these plates are self-transplanted into the ovary or another part of the body, such as the arm.
Fertility preservation for men
The preservation of male fertility is carried out by freezing sperm. However, there is another experimental technique, the freezing of testicular tissue, although it is not yet in practice.
In any case, the seminal quality of men who are going to undergo cancer treatment may be altered. For this reason, it is important for them to know how they can preserve their fertility. In this way, men will have the possibility of becoming parents once the cancer is over.
Each of the options for preserving male fertility is detailed below.
When a man is undergoing anti-tumor treatment (radiation or chemotherapy), sperm freezing is the simplest option for preserving male fertility. Moreover, it is currently the only alternative available to preserve men's reproductive function.
Other cases in which sperm freezing is indicated are the following:
- Patients who are having a vasectomy.
- Patients with poor sperm quality.
- Patients with difficulty in obtaining the sample.
- Sperm Donors
No medication is required for the freezing and storage of semen. The man simply must collect a semen sample with a previous sexual abstinence of 3 to 5 days. Once the sample has been obtained, its quality will be analysed in the laboratory by means of a seminogram.
Finally, the semen is processed to obtain the best quality spermatozoa and then placed in straws, which are sealed and stored in a semen bank. Frozen sperm samples will remain in storage until the man decides to have offspring.
Embryologist Antonio Alcaide tells us:
The limiting factor for freezing a sample is the quality of the sample, the quantity of spermatozoa and the number of spermatozoa that move.
Freezing of testicular tissue
Testicular tissue freezing is an experimental technique that is recommended in cases of young males who have not reached puberty, and therefore cannot freeze their semen.
The process is similar to freezing ovarian tissue. This involves removing small fragments of the cortex of the seminiferous tubules of the testicles, where the germ cells of the sperm are located. This tissue is then frozen until it can be used.
Prices vary depending on the treatment and complexity of the process. The simplest and least expensive technique is semen freezing, which costs between $1,000 to $1,200 on average.
Egg and embryos freezing is a more complex and laborious technique, so their cost is higher. Freezing embryos can cost $12,400, while freezing eggs costs about $11,900. In both cases, a process of hormonal stimulation is necessary, which is usually not included in the costs. Furthermore, an additional fee of $500 per year for storage is charged on average.
If you are considering preserving your fertility to have a baby in the future, we recommend that you start by getting a Fertility Report. In 3 simple steps, it will show you a list of clinics that fit your preferences and meet our strict quality criteria. Moreover, you will receive a report via email with useful tips to visit a fertility clinic for the first time.
FAQs from users
Is there an age limit on egg freezing?
In principle, there is no age limit on egg freezing; a woman can decide to do it whenever she wants. However, one should consider preserving her fertility at a young age, as egg quality is better at this point. This, at the same time, translates into higher chances of getting pregnant in the future by means of IVF.
How can you keep sperm alive outside the body?
The only possible way to do this is by means of sperm banking. Today's freezing methods allow us to store sperm and reach almost the same success rates as if it has not been frozen previously. Thanks to the cryoprotectants and ultra-rapid freezing methods used, sperm can be kept alive outside the body, without being damaged and with almost the same fertilization potential.
Can you freeze sperm and egg cells at home?
Reproductive cells cannot be stored at home. For egg and sperm cells to be available for later use, they have to be cryopreserved at special conditions. Moreover, in the case of egg freezing, surgery is necessary prior to storing the ova, so the woman has to necessarily visit an egg bank or fertility clinic.
How long does sperm last frozen?
Sperm can remain frozen indefinitely. The method used for sperm banking allows us to store the samples without causing any damage to them, and keeping their physical and functional properties almost intact.
Suggested for you
Throughout the article we have talked about freezing and vitrification. If you want to know the difference between these two terms, we recommend you to visit the following article: What is gamete and embryo freezing and vitrification?
In addition, preserving fertility is very important for cancer patients in order to have children in the future. If you are interested in this topic, you can continue reading in the next post: Preserving fertility in women with cancer.
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