What is Embryo Donation & Adoption?

By BSc, MSc (embryologist), MD, MSc (gynecologist), (medical director at fertty international), MD, FACOG, FACS, FACE (reproductive endocrinologist), (embryologist), MD, PhD (gynecologist) and (invitra staff).
Last Update: 05/25/2020

Embryo adoption is a reproductive treatment by which a couple tries to become pregnant by transferring the embryos left over from the in vitro fertilization (IVF) treatment of another couple, who have decided to donate them anonymously and altruistically.

For this reason, this technique is also known as embryo donation, as one couple donates the embryos and another adopts them. In this way, we can speak of two terms:

  • Embryo donation, from the point of view of the person or couple, donating their surplus embryos to help other couples.
  • Embryo adoption, from the point of view of the person or couple receiving embryos from other patients with the aim of achieving pregnancy.

Below you have an index with the 9 points we are going to deal with in this article.

What is embryo donation?

Embryo donation, embryo adoption is an assisted reproduction technique that consists of the transfer of embryos from one woman or couple to the uterus of another recipient woman. Therefore, the embryos that are transferred to the recipient woman carry the genetic load of other people.

This reproductive technique carries a great emotional burden since it implies the renunciation of genetic material. However, it is a simpler and less expensive technique than other assisted reproduction treatments.

Indications of embryo adoption

The Adoption of embryos is a reproductive alternative that is recommended in those cases where it is not possible to achieve pregnancy using one's own gametes. Normally, the most common situations are the following:

  • Both members of the couple with fertility problems, either due to poor egg quality or low seminal quality.
  • Women with fertility problems without male partner.
  • Previous failures in IVF cycles with own eggs.
  • Repeat miscarriages.
  • Possible transmission of genetic diseases.

Therefore, embryo adoption and double gamete (egg and sperm) donation are the options available to those women or couples with infertility problems who have difficulties in achieving a pregnancy.

Embryos left over from IVF treatment

From all the embryos obtained, the ones with the highest quality will be selected for transfer to the future mother's uterus, while waiting for the pregnancy to be achieved.

It is common to transfer between 1 and 2 embryos, although the law allows the transfer of up to a maximum of 3 embryos. The rest of the embryos that present good quality, the so-called leftover embryos, will be cryopreserved through the freezing process known as vitrification.

The couple must choose what to do with the cryopreserved embryos left over from their treatment:

  • Cryopreservation for own treatments in the future.
  • Donation for reproductive purposes, this means that the surplus embryos can be donated for fertility treatments of other couples.
  • Embryo donation for research.
  • Destruction. This option can be carried out when the woman's reproductive life has ended.

Generally, patients' first decision is to cryopreserve them for future transfers. However, when the couple decides that they no longer wish to have offspring, the option of donating the frozen embryos to others who wish to have children is an alternative.

It must be taken into account that patients will have to renew the informed consent for cryopreservation of embryos every two years, as well as pay for their maintenance according to the conditions of each assisted reproduction center.

Dr. Miguel Dolz comments that in order to donate embryos for reproductive purposes, the woman's egg has to be under 35 years old and free of pathologies, etc.

Advantages of adopting embryos

Embryo donation for reproductive purposes is an assisted reproduction treatment to which more and more patients are resorting.

For a couple with problems to conceive and after several failed attempts of other assisted reproduction techniques such as artificial insemination (AI) or in vitro fertilization (IVF), the possibility of adopting embryos is a great option due to its numerous advantages. Some of them are listed below:

  • No waiting list: access to treatment is quite direct, although it is necessary that the embryo shares a number of characteristics with the future parents: blood type, HR, phenotype features…
  • Endometrium preparation: the woman does not need ovarian stimulation as in the case of IVF. It is simply necessary to prepare the endometrium to encourage the implantation of the transferred embryos. The way to administer the medication (estrogen and progesterone) is simple: patches, oral medication, or vaginal tablets. The evolution of the endometrium is controlled by ultrasound.
  • Consultations: the preparation of the endometrium is simpler than ovarian stimulation for IVF. Also, fewer visits are necessary.
  • Costs: Embryo adoption costs less than IVF with your own eggs and much less than IVF with double gamete donation. Furthermore, the amount of medication is also reduced, which also means a reduction in the price of this reproductive technique.
  • Time: in the same year the patient can perform the entire treatment and have her baby. Once the transfer is programmed, depending on the state of the recipient's endometrium, the devitrification of the embryos and the transfer of the same is carried out in one day and after two weeks of waiting, the woman already takes a pregnancy test.

It is important to note that embryo donation, like gamete donation, can be open or anonymous , so prospective parents will not know the origin of the adopted embryos.

Success rates

The success rate of adoption treatment of embryos donated by another couple depends largely on the quality of the embryos. In this case, the characteristics of the recipient woman are not the most important, although they do have an influence.

The thawing of the embryos has very good survival rates since vitrification allows the recovery of the embryos in approximately 90% of the cases. Nevertheless, it is important to highlight that the embryos used when choosing this assisted reproduction treatment come from couples with fertility problems and, therefore, the probability of pregnancy is not very high.

According to data from the CDC, the birth rate with embryo donation was between 43-45% in 2017.

On the other hand, it must be taken into account that there is a possibility that the adopted embryos come from patients who have used eggs and/or sperm from donors for their IVF treatment. In this case, the quality of the embryos will be higher and therefore the probability of gestation may be increased.

Finally, before agreeing to undergo this type of reproductive treatment, the couple must be sure that they do not mind that the future baby does not have their genes, as well as understand all the bioethical and moral aspects that this process may entail.

Costs of embryo donation

As we have mentioned, embryo donation is an option to reduce the cost of assisted reproduction treatment.

The average price of embryo adoption ranges from $2,500 to $4000, depending on factors such as the fertility clinic, the tests needed for the process, the situation of each patient, or couple, etc.

Hormonal medication for endometrial preparation is not normally included in the total cost of treatment.

Interview with Elena de la Fuente

Dr. Elena de la Fuente explains that the majority of patients who come for embryo donation are couples who have undergone several assisted reproduction treatments that have led to repeated failures and miscarriages. They may also be women who suffer from premature menopause.

Depending on the hormonal situation of the patient, treatment is carried out:

  • in natural cycles with normal menstruation
  • with an estrogen-based hormone treatment to prepare the endometrium when hormone levels are insufficient.

In case you wish to undergo IVF with donated embryos to have a baby, we recommend that you get your Fertility Report now. This tool can offer you in real time a list of recommended clinics that meet our rigorous selection criteria, and we consider top fertility centers for our readers. The report you will receive will inform you about the prices and conditions that each clinic offers for embryo adoption.

FAQs from users

For embryo adoption, where do embryos come from?

By Dr. María Arqué (medical director at fertty international).

Embryos for embryo adoption come from other couples who have already completed their reproductive project and who have donated their surplus embryos so that other couples can have children.

These embryos may come from donor eggs or from the woman's own eggs, in which case she must have been under 35 years old when the ovarian puncture was performed. The sperm can come from the man himself or from a sperm donor.

Moreover, as per Law requirements, the parents of the donated embryos must not have any known infectious or genetic disease.

With an embryo donation, can I have problems of incompatibility or rejection of these embryos?

By Mark P. Trolice MD, FACOG, FACS, FACE (reproductive endocrinologist).

Rearkably, a woman’s uterus does not reject an embryo, even though it is half “foreign” due to fertilization by the mans’ sperm. More fascinating, the uterus accepts an embryo from a double-donation of egg and sperm. There are theories to explain why a woman’s uterus does not reject the embryo as foreign but no definitive reason has emerged.

Are the physical characteristics of both couples taken into account when the matching for embryo adoption is done?

By Andrea Rodrigo BSc, MSc (embryologist).

Yes, both in cases of gamete donation (eggs and sperm) and embryo donation, the medical team tries to match the physical characteristics of the donor with those of the recipient (e.g. blood type).

Is embryo adoption a valid choice for pro-life Catholics?

By Andrea Rodrigo BSc, MSc (embryologist).

The pro-life side of the Catholic Church is in favor of what they refer to as prenatal adoption, that is, adopting another couple's unused embryos from IVF.

Each year, over 600,000 embryos are thrown away only in the United States, so embryo adoption is a very valid option for Catholic families who suffer from infertility and wish to build their family through an alternative method.

In this sense, there exist various associations such as "Snowflakes Embryo Adoption and Donation", created by Nightlight Christian Adoptions, which pioneered embryo adoption in 1997. More than 480 babies have been born ever since.

For more information, please visit the following post: Religious views on gamete donation and embryo adoption.

Does embryo adoption qualify for tax credit?

By Andrea Rodrigo BSc, MSc (embryologist).

In the United States, embryo donation is not considered an adoption, but rather a property transfer by state laws. Taking this into account, those who adopt an embryo are not eligible for an adoption credit. However, the state of Georgia has enacted an statute called "Option of Adoption Act", which has made some couples eligible for Federal Adoption Tax Credit.

Are there embryo donation databases to assist in matching donated embryos to patients?

By Andrea Rodrigo BSc, MSc (embryologist).

Yes, there are donor embryo banks that allow you to search for embryos which characteristics resemble yours. Some even post pictures of the biological parents, while others are more private.

Online donor embryo banks assist in matching donated embryos to patients with whom they share a similar profile.

Donor embryo vs. donor egg, what is better?

By Andrea Rodrigo BSc, MSc (embryologist).

No technique is better than the other; it just depends on the characteristics of each patient and what is causing infertility. For instance, in cases where the male partner produces good-quality sperm, egg donation would be the most advisable treatment, as this allows for at least one of the intended parents to share his DNA with future offspring.

On the other hand, if both partners are infertile, double-donor IVF or embryo adoption would be the options of choice. In the former, the eggs and the sperms are of an excellent quality, as they both have been created using donor gametes. As for the latter, it involves using the spare embryos from the IVF cycle of another couple; although it is more affordable from the financial point of view, its success depends on the quality of the adopted embryos. Conversely, outcomes obtained by donation are usually satisfactory, but are dependent on the uterine conditions of the recipient.

As can be seen, several factors have an influence on such decision, so examining each case individually to determine what may be the most suitable option according to medical, economical and psychological aspects is crucial.

Should surplus IVF embryos be donated to stem cell research?

By Andrea Rodrigo BSc, MSc (embryologist).

Yes, embryo donation for stem cell research is a possible fate for surplus embryos. By choosing donating them for stem cell research, their cells can be used in research for tissue and organ development in vitro, which could help save lives in the future.

Are there options for an open embryo donation?

By Andrea Rodrigo BSc, MSc (embryologist).

Yes, open embryo donation is allowed in some countries. In that case, it works more similarly to traditional adoption of a live child. It is a more expensive process and requires a greater level of participation, though.

Given that an open embryo donation agreement is required, participants are required to seek legal representation.

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References

Authors and contributors

 Andrea Rodrigo
Andrea Rodrigo
BSc, MSc
Embryologist
Bachelor's Degree in Biotechnology from the Polytechnic University of Valencia. Master's Degree in Biotechnology of Human Assisted Reproduction from the University of Valencia along with the Valencian Infertility Institute (IVI). Postgraduate course in Medical Genetics. More information about Andrea Rodrigo
 Elena de la Fuente Díez
Elena de la Fuente Díez
MD, MSc
Gynecologist
Bachelor's Degree in Medicine from the University of Valladolid, with Ph.D in Obstetrics & Gynecology from the University of Valencia, and Master's Degree in Advanced Gynecological Endoscopic Surgery from the University of Augvergne. Physician specialized in Obstetrics & Gynecology, and currently works as an associate doctor at the Assisted Reproduction Unit of Ginemed Valencia (Hospital Vithas 9 de Octubre of Valencia). More information about Elena de la Fuente Díez
License: 462855729
Dr. María Arqué
Dr. María Arqué
Medical Director at Fertty International
Doctorate in Reproductive Medicine at the Autonomous University of Barcelona, specializing in Obstetrics and Gynecology. Dr. María Arqué has many years of experience as a Reproductive Medicine and Gynecologist Consultant and currently works as Medical Director at Fertty International. More information about Dr. María Arqué
Licence number: 080845753
 Mark P. Trolice
Mark P. Trolice
MD, FACOG, FACS, FACE
Reproductive Endocrinologist
Mark P. Trolice is the Director of Fertility CARE – The IVF Center and Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Central Florida College of Medicine. He is Board-certified in REI and OB/GYN, and maintains annual recertification. His colleagues select him as Top Doctor in America® annually, one among the top 5% of doctors in the U.S. More information about Mark P. Trolice
License: ME 78893
 Marta Barranquero Gómez
Marta Barranquero Gómez
Embryologist
Graduated in Biochemistry and Biomedical Sciences by the University of Valencia (UV) and specialized in Assisted Reproduction by the University of Alcalá de Henares (UAH) in collaboration with Ginefiv and in Clinical Genetics by the University of Alcalá de Henares (UAH). More information about Marta Barranquero Gómez
License: 3316-CV
 Miguel Dolz Arroyo
Miguel Dolz Arroyo
MD, PhD
Gynecologist
Bachelor's Degree in Medicine and Surgery from the Medicine Faculty of the University of Valencia (UV) and Doctor in Medicine, finished in 1988 and 1995, respectively. Physician specialized in Obstetrics & Gynecology. Expert in Reproductive Medicine, with more than 20 years' experience in the field. He is the Medical Director and founder of FIV Valencia. More information about Miguel Dolz Arroyo
License: 464614458
Adapted into english by:
 Romina Packan
Romina Packan
inviTRA Staff
Editor and translator for the English and German edition of inviTRA. More information about Romina Packan

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