In IVF treatments with donor eggs and/or sperm, success rates are higher if compared to cycles where own gametes (eggs and sperm) are used. This is due to the fact that donors are young persons who lead a healthy lifestyle, and are free from genetic abnormalities or diseases affecting their fertility.
A great number of factors have an influence when it comes to achieving a pregnancy, yet the gametes play a major role. Hence the greater number of success stories when donor egg and sperm cells are used.
Provided below is an index with the 10 points we are going to expand on in this article.
How are statistical data gathered?
By reproductive success we refer to a baby being born, and not to the pregnancy rate. However, more often than not, the success of fertility treatments is measured in accordance with the latter parameter instead of the former.
Calculating the statistics of each assisted reproductive treatment is a very useful tool to find out what may be your chances of getting pregnant using a particular fertility treatment.
Although these rates should be taken into account, relying on them too much when it comes to choosing one fertility clinic or another is not recommendable. This is due to the fact that basing our decisions only on statistics may easily lead to mistake.
The first aspect to consider when comparing between clinics is whether they are talking about the same results. There are various rates that may translate into success such as:
- The pregnancy rate, in which case we should distinguish between a positive HPT result or if pregnancy development till week 8-12 is taken into account.
- The birth rate
- The live birth rate, which clearly is the most important one.
Unluckily, the reality is that not every pregnancy is carried to term, that is, childbirth does not always occur; that is the reason why attention should be paid to the rates of miscarriage and embryonic arrest during development as well.
Another point to be borne in mind is how many fertility treatments does this clinic perform, since the data they are showing may not be representative. What we mean is the following: if, for instance, a clinic makes a treatment to a single patient per year and she becomes pregnant, the success rate will be 100%; however, it is only obvious that such rate has no value, since it is showing data obtained from a single case.
When should women consider using donor eggs?
There exist many causes leading women to opt for IVF with donor eggs to have a baby:
- Previous IVF failure
- A poor response to ovarian stimulation drugs, low egg and/or embryo quality (e.g. patients with endometriosis), IVF and/or implantation failure or recurrent pregnancy loss are the main reasons why a woman might not achieve success with IVF.
- Genetic abnormalities
- In case it is likely to be inherited by offspring, and cannot be detected by means of Preimplantation Genetic Diagnosis (PGD).
- Low egg supply or absent ovarian function
- Due to primary ovarian insufficiency, premature ovarian failure, menopause, or surgery in the ovaries.
- Advanced maternal age
- As a woman ages, the number and quality of a woman's eggs diminish significantly. From age 35 onwards, a woman might consider using donor eggs to prevent the transmission of chromosomal alterations that could compromise the viability of the embryos, which is more frequent at this point.
Whether what leads a patient to use donor eggs is related to the complete absence of ovarian function or because the quality of the eggs she produces is too low, considering donor-egg IVF is an option to achieve motherhood.
Odds of getting pregnant are higher if donor eggs are used instead of the woman’s own eggs, since donor eggs come from healthy, young women with a good ovarian reserve; therefore, donated eggs are of optimal quality.
IVF with own eggs vs. with donor eggs
The woman's age affects the chances for pregnancy with any fertility treatment. This is the reason why, in women over 40, the success rates of IUI are generally less than 5% per cycle. As far as IVF, although it is normally more effective, the statistics show that women aged 40 or older reach less than 20% per cycle.
In these cases, and especially in women over 42 who have not succeeded in previous IVF cycles using their own eggs, egg donation may offer them the opportunity to experience pregnancy, birth and motherhood, as it involves using the eggs of another woman who is in her 20s or 30s.
The following statistics should be taken into account when deciding whether to use donor eggs:
- By age 30, around 30% of the eggs a woman releases are chromosomally abnormal, while by ages 40-44, this figure rises to 60-90%.
- Donor eggs are normally used until about age 49, although some egg donation programs may accept 50-year-old patients.
- By age 43, the chances of achieving a successful pregnancy through IVF are less than 5%, and by age 45 egg donation turns out to be the only reasonable alternative.
- Clinical pregnancy rates and live birth rates are lower in recipients 45-50 years old, while the miscarriage rates are higher.
Some countries have established an upper age limit to receive donor eggs somewhere between 42 and 50 years of age. In some European countries such as Spain, this limit is set up by law, and therefore fertility clinics will not accept women older than 50. The law in the United States, however, does not address this aspect, though most IVF clinics have established their own age limit as well.
Success rates of donor-egg IVF by age
While the pregnancy success rates obtained in IVF cycles using the woman’s own eggs stand at 35-43% on average, the rates of donor-egg IVF cycles may increase to 55-63% approximately. They depend on uterine receptivity, a factor which has been examined by several authors.
There is evidence that implantation and clinical pregnancy rates are lower in women aged 45-50 than those younger. At the same time, the miscarriage rate increases if compared to women under 45. On average, the clinical pregnancy rate with donor eggs is 69% in patients under 45, while it reaches 63% when the recipient is 45-50 years old.
The above listed results apply only to fresh egg donor cycles. Should it be a frozen donor egg cycle, that is, the embryos are created from donor oocytes after embryo thawing, the success rates are slightly different:
- Pregnancy rate per transfer: 39.7%
- Birth rate per transfer: 24.7%
Nevertheless, these are just general figures and can vary depending on whether partner-donated or donor sperm is used, as well as in cases of double-donor IVF (egg donation + sperm donation). Also, we should keep in mind that these are just average rates, but they may vary from clinic to clinic by country.
Embryo quality is also a major factor. Evidence shows that day-5 blastocyst transfers allow patients to reach higher pregnancy rates as compared to day-3 transfers. Even though it relies on age, embryo quality has a greater impact on the outcomes as well.
The following are the live birth rates per embryo transfer of day-5 fresh embryos by female age:
- Under 35: 68.1%
- Age 35-37: 52.7%
- Age 38-40: 52.0%
- Age 41-42: 37.0%
The greater the number of attempts with donor-egg IVF, the higher the odds of success. Broadly speaking, most women achieve pregnancy after 3 or 4 cycles.
IVF with donor eggs is probably the most confusing of all fertility treatments, and oftentimes, a misleading one. Transparency is one of our strict selection criteria when it comes to recommending fertility clinics to our readers. You can create your Fertility Report now to filter clinics based on our selection criteria and get an individual report based on your preferences with answers to your queries and most importantly, to prevent potential frauds.
How many donor-egg cycles before success?
One of the most common frequently asked questions when it comes to getting started with donor-egg IVF is how many cycles are necessary before achieving pregnancy.
Thanks to the high success rates reached with these treatments, statistics show that a large number of patients are able to become pregnant on the first try.
Should a successful pregnancy not be achieved on the first try, it is estimate that the success rates after the third attempt reached 90% in most cases.
However, one should keep in mind that determining the precise number of attempts that each patient will need is difficult, as it varies on a case-by-case basis, and at the same time is dependent on various factors.
Reasons donor-egg IVF fails
The success rates of IVF treatments with donor eggs are generally high. However, the ultimate goal may not always be achieved, either because the embryos are unable to implant, or due to a miscarriage. This may happen as a consequence of:
- Uterine abnormalities
- Polyps, endometriosis, an intrauterine adhesion or septum, among others. As they may prevent or hinder implantation, surgery may be required before getting started with the treatment.
- Immune disorders
- The immune system should be working properly for implantation and a successful pregnancy to occur, as the mother's body should be capable of "accepting" the embryo.
- Blood clotting disorders (hypercoagulability)
- Clotting properly is essential for the chances for embryo implantation to rise, and therefore for a term pregnancy to take place.
- Genetic disorders
- The sperms may carry a genetic abnormality that prevents the embryo from developing.
- Poor embryo quality
- Low-quality spermatozoa may lead to poor-embryo quality. Also, it is possible, though unusual, for donor-egg quality to be low, in which case choosing another donor would be advisable.
Results by country
Many foreign countries count on databases where information regarding the success rates of each fertility treatment is made public, including those obtained after using donated eggs or sperm.
Getting an overall picture of how do fertility treatments work on a particular country is possible thanks to the creation of this sort of reports.
Nevertheless, taking into account a series of aspects is crucial in order to compare between countries:
- Enabling these databases may be optional rather than compulsory, which means that not every fertility clinic will make their data public despite being located in the same country.
- Shown rates can be different; that’s why the pregnancy rate is not to be confused with the rates of birth and live birth.
- Regulations on this field have an influence on the results, given that not all techniques are allowed in the same ways worldwide.
An example of the impact that legislation may have on IVF results is related to the amount of embryos to transfer permitted by law. Within the US or India, the maximum number of embryos that can be transferred is not enforced by law. Thus, it is not uncommon to perform 4-embryo o more transfers among clinics located in these countries.
In Spain or Italy, a 3-embryo transfer is the legally marked limit. Obviously, this automatically translates into slightly lower pregnancy success rates. However, it reduces the risk of having a multiple pregnancy.
In the UK, there is an average 25-40 percent rate for each cycle if donated oocytes are used, according to data provided by the HFEA (Human Fertilisation & Embryology Authority). Again, this rate is higher than that reached in conventional IVF cycles with own eggs across all age groups.
As for Cyprus, success rates are handled differently depending on the region where the clinic is located. In the North (Northern Cyprus), there is no law which forces clinics to submit their results to a governing body. In the South, inversely, there exists a governing body with regulates the results provided by each clinic.
FAQs from users
Does using frozen donor eggs impact the success of IVF?
The truth is, the success rates with frozen donor eggs can vary greatly from clinic to clinic. Sometimes, the chances of success are not altered by using frozen oocytes at all, while in other cases, if the clinic does not master the egg vitrification technique, egg quality can be lower.
What are the success rates with donor eggs in women over 40?
With donor eggs, the chances of getting pregnant stand at 50-70% per cycle for women in their forties. It should be kept in mind that uterine receptivity might decline with advanced age. The reasons behind it might include biochemical and/or molecular aberrations of the endometrial lining, incidence of pathological conditions in the uterus (e.g. polyps, myomas...), hypertension, etc.
What are the chances of Down syndrome with donor eggs?
Egg donation pregnancies have lower rates of complications, including miscarriage and Down syndrome. You should keep in mind that the donor is younger and her oocytes are able to produce embryos with lower chances of having chromosomal abnormalities.
How successful is IVF with donor eggs?
In general, the use of donor eggs makes an IVF treatment more likely to succeed, as the oocytes have been donated by young, healthy girls who enjoy a good ovarian reserve, features that make the quality of the eggs they produce optimal.
In comparison, if the normal pregnancy rate of IVF with own eggs stands at 35-34% on average, with donor eggs it increases to up to 55-63% approximately. These figures, however, depend on the uterine receptivity of the patient.
Visit the following article to learn more: Pregnancy success rates with donor eggs.
Why does donor-egg IVF fail?
Several complications not necessarily related to egg quality can lead to IVF failure or the impossibility to carry the pregnancy to term in spite of having used donor eggs, including:
- Genetic abnormalities, which might lead to embryonic arrest at any point of embryo development
- Uterine alterations that might prevent the embryo from continuing its development and cause the woman to miscarry
- Implantation failure due to poor endometrial receptivity
What are the miscarriage rates with donor eggs?
While in women younger than 45, the implantation rate is 45% on average, it drops to 35% in women from the 45-50 age group. Subsequently, the miscarriage rates increase with age in spite of using donor eggs: while they are less than 10% when the woman is 45 or less, they stand at 16% on average for women over 45. As explained above, a decline in endometrial receptivity is usually the reason behind this.
What are the chances of twins with donor eggs?
The chances of twins with egg donation are higher than in normal IVF cycles using the woman's own eggs due to the young age of donors, which translates into very healthy oocytes. This is the reason why multiple embryo transfers are unadvisable.
On average, if more than one embryo is transferred, the likelihood of becoming pregnant with twins is about 40%, while the chances of carrying triplets or greater is roughly 4%.
What are the best success rates for donor-egg IVF abroad?
Success rates vary by country, but also from clinic to clinic, so choosing a single destination as the best according to general statistical data is difficult. We recommend you to take a look at this map: Egg donation rates worldwide.
Additionally, our advice is that you choose the clinic that best fits your needs, in accordance with factors such as your particular fertility issue, budget, etc.
What are the donor-egg success rates over 40?
With donor eggs, the chances of getting pregnant with donor eggs at age 40-45 reach about 50% in most cases, while with non-donor eggs, they are as low as 19%.
Suggested for you
If you want to learn more about the egg donation process step by step, we recommend that you read the following post: Recipient guide to IVF using donor eggs.
Also, if you have already undergone donor-egg IVF and gotten a successful outcome, you may wish to learn more about the development of pregnancy after using donor eggs, the symptoms you may experience, etc. Visit this post to delve deeper into it: Pregnancy signs after getting pregnant with donor eggs.
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FAQs from users: 'Does using frozen donor eggs impact the success of IVF?', 'What are the success rates with donor eggs in women over 40?', 'What are the chances of Down syndrome with donor eggs?', 'How successful is IVF with donor eggs?', 'Why does donor-egg IVF fail?', 'What are the miscarriage rates with donor eggs?', 'What are the chances of twins with donor eggs?', 'What are the best success rates for donor-egg IVF abroad?' and 'What are the donor-egg success rates over 40?'.