Understanding the Results of Preimplantation Genetic Diagnosis

By BSc, MSc (embryologist) and BA, MA (fertility counselor).
Last Update: 06/03/2014

Information about the embryo's set of chromosomes can be obtained by means of a PGD. Thus, only genetically approved embryos will be loaded into the maternal uterus through embryo transfer.

For this reason, PGD is considered to increase the chances for embryo survival. If it had some kind of aneuploidy, in many cases it would be non-viable and therefore miscarriage would occur.

Below you have an index with the 3 points we are going to deal with in this article.

Factors that influence embryo implantation

An embryo with no chromosomal alteration does not have more chances for implantation, since implantation depends on many other factors such as:

  • Great amount of fragments in the embryo's cytoplasm occupying space and hindering embryo development
  • Incapability of breaking through the zona pellucida to implant
  • Slower-than-normal cleavage rate
  • The endometrium is not prepared for implantation

Does PGD increase chances of pregnancy?

In conclusion, an increased pregnancy rate has been noticed in women who are within the range of patients for whom this technique is indicated.

In women for whom PGD is not indicated, not only the pregnancy rate does not increase, but also it can even diminish, since handling an embryo can stop its development if it was not in good condition.

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 Neus Ferrando Gilabert
Neus Ferrando Gilabert
BSc, MSc
Bachelor's Degree in Biology from the University of Valencia (UV). Postgraduate Course in Biotechnology of Human Assisted Reproduction from the Miguel Hernández University of Elche (UMH). Experience managing Embryology and Andrology Labs at Centro Médico Manzanera (Logroño, Spain). More information about Neus Ferrando Gilabert
Adapted into english by:
 Sandra Fernández
Sandra Fernández
Fertility Counselor
Bachelor of Arts in Translation and Interpreting (English, Spanish, Catalan, German) from the University of Valencia (UV) and Heriot-Watt University, Riccarton Campus (Edinburgh, UK). Postgraduate Course in Legal Translation from the University of Valencia. Specialist in Medical Translation, with several years of experience in the field of Assisted Reproduction. More information about Sandra Fernández

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