Like the vast majority of testing techniques, PGD also has a small error rate, which could lead to false positives and negatives.
This depends mainly on the technique used for the genetic analysis. For example, the FISH technique only allows a maximum of 12 chromosomes to be analyzed, whereas with the latest massive sequencing techniques all chromosomes can be analyzed and a reliability of 96-98% is obtained.
However, it is also necessary to take into account the possible mosaicism (two different types of cell lines) caused by a very early error in embryonic development. Nowadays, thanks to the biopsy of several cells in the blastocyst, it is possible to detect this mosaicism and decrease the probability of PGD error.
Read the full article on: Understanding the Results of Preimplantation Genetic Diagnosis ( 58).
Zaira Salvador
B.Sc., M.Sc.
Bachelor's Degree in Biotechnology from the Technical University of Valencia (UPV). Biotechnology Degree from the National University of Ireland en Galway (NUIG) and embryologist specializing in Assisted Reproduction, with a Master's Degree in Biotechnology of Human Reproduction from the University of Valencia (UV) and the Valencian Infertility Institute (IVI)
License: 3185-CV
