Advanced paternal age (APA) is usually defined above age 35-40 and is associated with decreasing sperm analysis parameters. Men above age 45 have approximately 5 times as long to achieve a pregnancy compared with men less than 25 years of age. Further, there is evidence for APA increasing risk of miscarriage, birth defects, and autism. Men older than 40-45 have a twice as likely risk of an autistic child and five times higher risk of a child with schizophrenia.
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