Advanced paternal age (APA) is usually defined above age 35-40 and is associated with decreasing sperm analysis parameters. Men above age 45 take approximately 5 times longer to achieve a pregnancy compared with men less than 25 years of age. Further, there is evidence for APA increasing risk of miscarriage, birth defects, and autism. Men older than 40-45 have a twice as likely risk of an autistic child and five times higher risk of a child with schizophrenia.
Does the man's age affect the quality of his sperm?
By Mark P. Trolice M.D., F.A.C.O.G., F.A.C.S., F.A.C.E. (reproductive endocrinologist).
Last Update: 08/08/2022
Mark P. Trolice
M.D., F.A.C.O.G., F.A.C.S., F.A.C.E.
Mark P. Trolice is the Director of Fertility CARE – The IVF Center and Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Central Florida College of Medicine. He is Board-certified in REI and OB/GYN, and maintains annual recertification. His colleagues select him as Top Doctor in America® annually, one among the top 5% of doctors in the U.S.
License: ME 78893