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Is there incompatibility if the foetus is Rh negative and the mother is Rh positive?

By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).
Last Update: 06/16/2023

No. In this case there would be no Rh incompatibility even if they are different. The reason is that if the foetus is Rh negative, it does not have the Rh antigen on the surface of its red blood cells, so it cannot trigger the production of maternal anti-Rh antibodies.

Rh isoimmunisation only occurs if the mother is Rh negative and the foetus is Rh positive (because it has inherited it from the father). For this reason, there is sometimes talk of Rh incompatibility in the couple, since for this to occur (the baby being Rh positive while the mother is Rh negative) the father must be Rh positive.

 Silvia Azaña Gutiérrez
Silvia Azaña Gutiérrez
B.Sc., M.Sc.
Embryologist
Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics.
License: 3435-CV
Embryologist. Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics. License: 3435-CV.