There exist several genetic mutations of different types of inheritance that can cause someone to develop Kallmann Syndrome:
- Sex-linked inheritance: KAL1 (Xp22.32)
- Autosomal dominant inheritance: FGFR1 (8p12), FGF8 (10q25-q26), CHD7 (8q12.2), and SOX10 (22q13.1)
- Autosomal recessive inheritance: PROKR2 (20p12.3), and PROK2 (3p21.1)
Depending on the mutation and gene affected, carriers of Kallmann Syndrome have no choice but to conceive using reproductive technologies in order to prevent the transmission of this genet to offspring.