Globozoospermic sperm resemble a balloon, hence the name (from globe (from Latin globus, ‘spherical object’). These sperm lack an acrosome, a small deposit located at one end of the head, and which contains a substance that is able to weaken the egg coat, allowing the sperm to penetrate it.
For this reason, balloon-shaped sperm cannot fertilize an egg either naturally or artificially with a fertility treatment like IUI or IVF. Only if ICSI is used, where the embryologist injects the sperm cell manually into the egg cell, fertilization with globozoospermic spermatozoa is possible.
In short, achieving a full-term pregnancy with globozoospermia is unlikely. Moreover, these sperms can carry genetic abnormalities.
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