The Preimplantation Genetic Test (PGT) allows the detection of genetic abnormalities in the embryos, before their transfer to the woman's uterus. Identifying embryos free of chromosomal abnormalities and genetic mutations can prevent their transmission to offspring.
The more embryos available for PGT, the greater the chances of obtaining healthy embryos suitable for transfer to the woman's uterus. Advances in embryo culture and biopsy techniques have made it possible for the genetic analysis of embryos to be carried out at the blastocyst stage, allowing a greater quantity of cells to be obtained (trophoectoderm) and maintaining the integrity of the embryo and its capacity for implantation.
However, ovarian reserve and ovarian response to gonadotropin stimulation are inversely related to maternal age, since the older the mother, the lower the reserve and response. Consequently, advanced maternal age affects the number of oocytes, their quality and the number of embryos available for biopsy.