No. They are two different diagnostic tests that are performed on the male as part of a "non-basic" sterility study, that is, in specific cases to complete the male study, but not for all males.
The DNA fragmentation test measures the integrity of the genetic material of a semen sample, analyzing the breaks or lesions that may be present in the DNA chains of the spermatozoa. These breaks can be in a single strand or in both strands (double stranded). A certain percentage of breaks in the DNA chain is normal in humans, but when these are found in a higher percentage than what is considered normal, it can cause fertility problems, fertilization can be reduced and embryo development can be affected.
FISH (Fluorescent In Situ Hybridization) in spermatozoa allows us to evaluate the genetic material of spermatozoa. This test allows us to study whether the spermatozoa carry an abnormal chromosomal endowment (for the chromosomes analyzed, which can be 5 or 9) in a higher proportion than normal for the population. Usually, 5 chromosomes are analyzed (sex chromosomes X and Y, 13, 18 and 21).
Sperm FISH is indicated in patients with a history of miscarriage, previous IVF failures or severe male factors.
