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Are Y chromosome microdeletions always studied in men with oligozoospermia in the semen analysis?

By Mónica Aura Masip M.D., M.Sc. (gynecologist).
Last Update: 01/12/2024

Y chromosome microdeletions should be studied only in males with concentrations of less than 5mill/ml of sperm or in males with azoospermia, which are the population with the highest percentage of finding these alterations. However, Y chromosome microdeletions are very infrequent in patients with normal semen or moderate or mild oligozoospermia.

Among the microdeletions of the Y chromosome, the most frequent are aZFc (66% of cases) and the least frequent and with the worst reproductive prognosis are aZFb and aZFa.

Imagen: Oligozoospermia and Y-chromosome microdeletions
 Mónica  Aura Masip
Mónica Aura Masip
M.D., M.Sc.
Gynecologist
Dr. Mónica Aura has a degree in Medicine and General Surgery from the Autonomous University of Barcelona (UAB). She is also a specialist in Gynecology and Obstetrics from the Hospital de Santa Creu y Sant Pau and has a Master's degree in Human Assisted Reproduction from the University Juan Carlos I of Madrid and another in Health Center Management from the UB.
Licence number: 31588
Gynecologist. Dr. Mónica Aura has a degree in Medicine and General Surgery from the Autonomous University of Barcelona (UAB). She is also a specialist in Gynecology and Obstetrics from the Hospital de Santa Creu y Sant Pau and has a Master's degree in Human Assisted Reproduction from the University Juan Carlos I of Madrid and another in Health Center Management from the UB. Licence number: 31588.