Women who have POF may have irregular menstrual cycles. In this way, pregnancy can be achieved spontaneously, but the vast majority of women will suffer from infertility problems.
Some authors have proposed treatments to try and restore ovarian function.
One possible option would be treatment with estrogens to lower FSH levels and increase ovarian response to stimulation, the use of steroids in the case of POF of autoimmune origin, or the use of dehydroepiandrosterone (DHEA) to increase the number of antral follicles. However, all of them have little success.
New approaches have recently emerged that may be promising based on the premise that some women with POF may still have preantral follicles. Fragmentation of ovarian tissue appears to be able to activate these preantral follicles, and some studies have already published pregnancies with this type of procedure.
Another possibility would be the use of stem cells to rescue the remaining follicles, and there are also published pregnancies with this technique.
All these techniques could be a possible solution for women with IOP in the future, but for the time being they must remain in the field of research, since more studies are needed to evaluate their efficacy and safety.