In vitro fertilization (IVF), specifically by intracytoplasmic sperm injection (ICSI), may be the solution for patients with Y chromosome microdeletions to have children.
However, ICSI can only be performed if sperm can be obtained from the male (either from the ejaculate or by testicular biopsy), which is more frequent in the case of microdeletions in the AZFc region of the Y chromosome.
In this case, it is very important that patients also receive genetic counseling, as the male offspring will inherit the paternal Y chromosome microdeletions.
On the other hand, in the event that sperm cannot be obtained, patients with Y chromosome microdeletions can opt for sperm donation or adoption to become parents.
Read the full article on: How is male infertility caused by Y chromosome microdeletions? ( 51).

Silvia Azaña Gutiérrez
B.Sc., M.Sc.
Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics.
License: 3435-CV