IVM (In Vitro Maturation) of oocytes is a technique that has been known for more than 20 years, but its clinical application remains very limited. The pregnancy rate results when IVM is applied are still worse than with IVF.
However, there are some cases where IVM can provide advantages over IVF:
- To optimize the performance of patients with low response. There are cases in which women respond less than expected to ovarian stimulation, so there are small follicles that do not grow with medication. These follicles can be aspirated along with the rest of the large follicles on the day of the puncture resulting in obtaining immature oocytes that could be matured in vitro to obtain more embryos after IVF.
- For women to whom the administration of gonadotropins for ovarian stimulation is contraindicated..
- For patients with polycystic ovaries and high risk of ovarian hyperstimulation using gonadotropins.
- For oncologic patients or patients with other pathologies that require urgent fertility preservation.
In the cases mentioned above, IVM is becoming more important, since it would allow us to increase the number of oocytes to be preserved without having to wait longer and without having to undergo more hormonal treatment before proceeding with the treatment of the disease.