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What are the consequences of Kartagener's syndrome on spermatozoa?

By José María Sánchez Jordán M.D. (gynecologist).
Last Update: 09/27/2023

Kartagener's syndrome is an autosomal recessive genetic disorder that affects ciliary movement in general, producing bronchiectasis and sinusitis due to poor mucus elimination due to ciliary malfunction. This syndrome was discovered by Manes Kartagener in 1933, who gave his name to this syndromic condition which, by affecting ciliary movement, also affects the mobility of the sperm flagellum.

In this sense, the spermatozoon that is alive and of adequate morphology does not have the capacity to move, this is what we know as asthenozoospermia. Pregnancy in these cases is impossible because the sperm cannot reach the egg on its long journey from the vagina to fertilise the egg in the fallopian tube, unless an assisted reproduction technique is used.

In this way, by taking a semen sample, the lack of displacement is confirmed in live and morphologically normal spermatozoa. In the laboratory, using the ICSI technique, the sperm is brought into contact with the egg in order to achieve fertilisation and, therefore, pregnancy.

 José María  Sánchez Jordán
José María Sánchez Jordán
M.D.
Gynecologist
Dr. José María Sánchez has a degree in Medicine and Surgery from the Faculty of Medicine of Malaga and specialized in Obstetrics and Gynecology.
Member number: 511104002
Gynecologist. Dr. José María Sánchez has a degree in Medicine and Surgery from the Faculty of Medicine of Malaga and specialized in Obstetrics and Gynecology. Member number: 511104002.