In the case of male infertility of testicular origin, there are two different origins. On the one hand, there is the congenital origin in which the problem of infertility in the male is present from the birth of the individual.
On the other hand, male infertility due to testicular factor can also have an acquired origin, that is, throughout the male's life is when the cause of infertility occurs.
The most common causes of congenital male infertility of testicular cause are:
- Genetic causes
- certain genetic mutations that can be inherited from the parents or that occur de novo in embryonic development. For example, this is the case of microdeletions of the Y chromosome, Klinefelter syndrome, Noonna syndrome. Sertoli syndrome or others.
- Alterations during embryonic development without genetic cause
- can be caused by hormonal alterations in the fetus or in the mother, they can also be due to errors in the migration of germ cells in the formation of the gonads or because these cells enter apoptosis (programmed cell death of unknown cause). Alterations in embryonic development may manifest with testicular agenesis, testicular dysgenesis, cryptorchidism, oligozoospermia and / or azoospermia.