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What is the treatment for fatherhood with retrograde ejaculation?

By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).
Last Update: 09/04/2026

Silvia Azaña, an embryologist at inviTRA, tells us in this video what the treatment is for seeking a pregnancy with retrograde ejaculation:

In general, men with retrograde ejaculation do not need specific treatment for this condition unless they are trying to conceive with their partner, as retrograde ejaculation is a condition that has consequences for male fertility. In that case, it will be important to assess the cause.

If the condition is a consequence of medication administration, the doctor may recommend discontinuing it or changing the medication to avoid this side effect of retrograde ejaculation. When there are nerve injuries, specialists may prescribe certain medications. The goal is to facilitate the closure of the bladder sphincter during ejaculation.

If the mentioned treatments do not work or are not possible, it is complicated to achieve pregnancy naturally with retrograde ejaculation, as most or all of the man's sperm will be found in the urine. However, there are several treatment options to achieve pregnancy.

The most commonly used in fertility clinics involves the man, after a few days of abstinence (2 to 4 days), after having consumed bicarbonate, and with an empty bladder, masturbating to see if he can collect some ejaculate in a container. If successful, the semen sample will be analyzed in the laboratory.

Regardless of whether a semen sample has been collected, the man must collect urine after masturbation, as this is where most sperm will be found. Then, these sperm are separated from the urine and prepared in the laboratory to be used in an assisted reproduction technique suitable for the patient's sperm concentration and motility.

It is most likely that artificial insemination or in vitro fertilization will be sufficient to try to achieve a pregnancy in patients suffering from retrograde ejaculation. On the other hand, it would also be possible to perform a testicular biopsy or sperm aspiration from the epididymis to obtain sperm directly from the testicle or epididymis.

Despite this, if the quality of the sperm obtained in the laboratory is not good, another alternative would be to resort to fertility treatment with donor sperm.

 Silvia Azaña Gutiérrez
Silvia Azaña Gutiérrez
B.Sc., M.Sc.
Embryologist
Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics.
License: 3435-CV
Embryologist. Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics. License: 3435-CV.