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When is egg donation required?

By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).
Last Update: 11/21/2025

IVF with egg donation is not usually the first option when a woman or couple comes to a fertility clinic, as patients generally prefer to try to achieve pregnancy with their own gametes first. However, the situations in which egg donation is clearly indicated are the following:

  • Patients with no ovarian function, whether due to premature ovarian insufficiency, absence of ovaries, menopause, etc.
  • Patients who have ovarian function but cannot use their own eggs due to transmissible genetic abnormalities.

Egg donation may also be indicated after repeated failures in previous IVF cycles and when the woman is over 40 years old. This last indication is quite common, since egg quality decreases with age. As a result, the likelihood increases that the embryos obtained will have chromosomal abnormalities that compromise their viability and may lead to miscarriage or to the birth of a baby with conditions such as Down syndrome.

 Silvia Azaña Gutiérrez
Silvia Azaña Gutiérrez
B.Sc., M.Sc.
Embryologist
Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics.
License: 3435-CV
Embryologist. Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics. License: 3435-CV.