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Genetic causes of Klinefelter syndrome
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Genetic causes of Klinefelter syndrome

The main causes of children born with Klinefelter syndrome are errors during meiosis, a process required for the production of male and female gametes (egg and sperm cells).

As a result, and due to a nondisjunction of a pair of chromosomes during cell division, the child has an extra X chromosome. Subsequently, when this gamete meets a gamete of the opposite sex after fertilization, the resulting embryo will have the XXY trisomy, which is the most common genotype of males affected by KS.

By MD, MSc, PhD (gynecologist), BSc, MSc, PhD (senior clinical embryologist), BSc, MSc (embryologist) and BA, MA (fertility counselor).
Last Update: 04/10/2018