Some of the factors that cause high sperm DNA fragmentation are modifiable. Therefore, the first approach would include lifestyle changes, treating a possible genital infection, or intervening on a varicocele. In case of taking antioxidants, it must always be under medical prescription.
If after 3 months (one spermatogenesis cycle) the sperm DNA fragmentation remains high, an option would be to perform an ICSI with sperm extracted directly from the testicle.
Read the full article on: Daily habits hide severe sperm DNA damage ( 37).
By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).
Last Update: 06/25/2026
