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Does sperm DNA fragmentation cause birth defects?

By Marta Barranquero Gómez B.Sc., M.Sc. (embryologist).
Last Update: 06/10/2026

Actually, there is no human study showing a direct relationship between birth defects and sperm DNA fragmentation. However, damage in the sperm DNA increases the risks increases the risk of genetic mutations, thereby increasing the risk of miscarriage.

 Marta Barranquero Gómez
Marta Barranquero Gómez
B.Sc., M.Sc.
Embryologist
Graduated in Biochemistry and Biomedical Sciences by the University of Valencia (UV) and specialized in Assisted Reproduction by the University of Alcalá de Henares (UAH) in collaboration with Ginefiv and in Clinical Genetics by the University of Alcalá de Henares (UAH).
License: 3316-CV
Embryologist. Graduated in Biochemistry and Biomedical Sciences by the University of Valencia (UV) and specialized in Assisted Reproduction by the University of Alcalá de Henares (UAH) in collaboration with Ginefiv and in Clinical Genetics by the University of Alcalá de Henares (UAH). License: 3316-CV.