Certified Medical Magazine by WMA, ACSA, HON
FAQs
12
0

Does the endometrium continue to grow after Ovitrelle administration?

By Júlia Roig Navarro M.D. (gynecologist).
Last Update: 05/17/2023

The endometrium is the tissue that lines the inside of the uterus and it undergoes changes in size according to the phases of the menstrual cycle.

After shedding by menstruation, it begins to grow thanks to the effect of oestrogen, which is called the follicular phase (as it coincides with the growth of the follicles) or proliferative phase. The endometrium grows from 1-3 mm to 6-12 mm during this period.

At the time of ovulation, the follicle also begins to produce progesterone. We move on to the secretory phase which, under the effect of oestrogen and progesterone, the endometrium continues to grow up to 10-16 mm. As can be seen, endometrial thickness varies from phase to phase and from person to person.

When Ovitrelle is administered, we are in the late proliferative phase, and the endometrium normally measures more than 6 mm. After 36-40 hours of administration, ovulation will occur, initiating the production of endogenous progesterone, which is normally complemented by the use of external progesterone. The endometrium will continue to grow due to oestrogens after the administration of Ovitrelle and also after ovulation/puncture. However, it should be kept in mind that most of the studies where endometrial thickness is assessed are done before the administration of Ovitrelle, so the valid measurement will be the one we can compare with existing studies.

If the studies indicate that there is greater implantation when the endometrium is trilaminar and equal to or greater than 6-7 mm prior to Ovitrelle or the onset of progesterone, if we want to achieve this measurement, it should also be at that time, without taking into account that the endometrium will continue to grow afterwards.

 Júlia Roig Navarro
Júlia Roig Navarro
M.D.
Gynecologist
Dr. Júlia Roig has a degree in Medicine and General Surgery from the University of Barcelona (UB). In addition, she is a specialist in Gynecology and Obstetrics at the Hospital Universitari Arnau de Vilanova and has a Master in Human Assisted Reproduction from the Complutense University of Madrid and did an internship at the Quirón Dexeus center in Barcelona.
Member number: 56030
Gynecologist. Dr. Júlia Roig has a degree in Medicine and General Surgery from the University of Barcelona (UB). In addition, she is a specialist in Gynecology and Obstetrics at the Hospital Universitari Arnau de Vilanova and has a Master in Human Assisted Reproduction from the Complutense University of Madrid and did an internship at the Quirón Dexeus center in Barcelona. Member number: 56030.