In the event that the woman is seropositive and the man is seronegative, it is always advisable to vaccinate the man against hepatitis B before attempting a pregnancy. It is not recommended to have unprotected sexual relations until it is verified that the man has acquired immunity against the virus.
In addition, if it is necessary to resort to assisted reproduction, any technique is discouraged until:
- Submit the infection.
- HBeAg antigens is negative, since if the HBeAg is positive it would mean that there is hepatitis B infection.
- Serum viral load less than 1 million copies/mL.