In a recent study (Sarrate et al, 2019), we studied which indications are most frequently associated with an altered FISH and, therefore, may benefit from its study. The results showed that these were severe oligoastenothermia (<5 million sperm/ml), oligozoospermia and teratozoospermia (asthenozoospermia is not related to altered FISH). In addition, the patient profile in which we most frequently find an altered FISH will be a middle-aged male (between 35 and 60 years), with oligothermia and a history of implantation failure in previous IVF treatments.Furthermore, it seems logical to propose this study in couples with repeated miscarriages. It has been a classic indication, maintained by the majority of authors and in the aforementioned study, up to 22.6% of couples with this circumstance found an altered FISH.
Suggested for you: Fluorescent in situ hybridization (FISH): Alterations in Sperm Cells.