When asked what the treatment of choice is for a 40-year-old woman, if what we want is the assisted reproduction treatment with the highest clinical gestation rate, the answer is a treatment of receiving donated eggs. This treatment, by using a young woman's eggs, allows for much higher pregnancy rates and healthy newborns.
Although egg donation is the treatment with the highest success rate in women of 40 years of age, it is possible to consider carrying out In Vitro Fertilization (IVF) with one's own eggs depending on the woman's reproductive desires and taking into account her ovarian reserve.
In the case of carrying out an IVF with one's own eggs, a Pre-implantation Genetic Diagnosis (PGD) can be considered to exclude those embryos with chromosomal alterations secondary to age that would not result in a healthy newborn. The application of PGD must be evaluated in each case individually (number of embryos, economic cost, etc.).