Which prenatal diagnostic test is best suited to detect Down syndrome?
The simplest test that poses no risk to the mother or the fetus is the maternal blood fetal DNA test. This test is very accurate in detecting the trisomy of chromosome 21, which is responsible for Down syndrome.
However, the cost of the test is around 500-600€, so if there is no high risk of chromosomal anomalies, future parents usually only do the combined screening of the first trimester.
Finally, invasive prenatal diagnostic tests also detect pathologies such as Down syndrome with very high reliability.