Assisted reproductive techniques for Y chromosome microdeletions

When the male is diagnosed with microdeletions of the Y chromosome in the AZFc region, it is very possible that sperm can be recovered by testicular biopsy or even in the ejaculated semen (when the male has oligozoospermia).

These recovered sperm can be used to search for pregnancy by assisted reproductive techniques, specifically intracytoplasmic sperm injection (ICSI).

However, the male offspring will inherit the paternal Y chromosome microdeletions, so patients are required to undergo genetic counseling before seeking pregnancy.