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Approximately how many injections does ovarian stimulation require?

By Daniel Sosa M.D., M.Sc. (gynecologist on Ovoclinic Marbella).
Last Update: 08/19/2022

Ovarian stimulation treatments require medication that is generally administered subcutaneously by injection. Depending on the ovarian stimulation protocol chosen by the specialist, through the personalization of the treatment, the number of injections that the patient must apply will vary.

As a general rule, the duration of treatment and therefore the number of injections to be administered will also be modified depending on the ovarian response, faster or slower, depending on the case.

In the long protocols with GnRH Agonists, in which the administration of injectable medication begins on the 21st day of the previous cycle and considering that the doctor has chosen to perform stimulation with daily administration of gonadotrophins, in On average, approximately 27-29 injections may be required.

In short protocols with GnRH Agonists, in which the administration of injectable medication begins on the 1st day of the cycle and considering that daily gonadotrophins are used, on average approximately 20-22 injections.

Imagen: number-injections-based-protocol-agonists-gnrh

In the ultrashort protocols with GnRH Agonists, in which the administration of injectable medication is started on the 1st day of the cycle while using daily gonadotrophins, on average approximately 13-14 injections may be required .

In any of the above options, provided that the specialist has chosen to start treatment with a long-acting gonadotropin, the number of injections will be reduced by approximately 5-7.

In the cases of protocols with GnRH Antagonists, in which the administration of injectable medication is started on the 2nd or 3rd day of the cycle, on average approximately 15-16 injections may be required.

In addition, in all the cases mentioned above, 1 or 2 injections will have to be added for the ovulatory discharge.

 Daniel Sosa
Daniel Sosa
M.D., M.Sc.
Gynecologist on Ovoclinic Marbella
Degree in Medicine from the National University of Tucumán in Argentina. Specialist in Gynecology and Obstetrics. Master in Human Reproduction by the Universidad Rey Juan Carlos and the Instituto Valenciano de Infertilidad (IVI). Current medical director of the clinic FIV Marbella.
Licence number: 290846745
Gynecologist. Degree in Medicine from the National University of Tucumán in Argentina. Specialist in Gynecology and Obstetrics. Master in Human Reproduction by the Universidad Rey Juan Carlos and the Instituto Valenciano de Infertilidad (IVI). Current medical director of the clinic FIV Marbella. Licence number: 290846745.