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When is FISH recommended for spermatozoa?
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When is FISH recommended for spermatozoa?

The FISH or in-situ hybridization technique allows the chromosomal endowment of spermatozoa to be determined. Most commonly, probes are used to detect alterations in chromosomes 13, 18, 21, X and Y. This complementary technique is especially indicated in patients with implantation failure in previous IVF cycles or repeated miscarriages, but also in men:

  • Undergoing oncological treatment of radiotherapy and/or chemotherapy.
  • Previous pregnancy with a chromosomal alteration.
  • Karyotype alterations.
  • Infertility of unknown origin (EOD).
  • Advanced paternal age.
By (gynecologist), (embryologist), (gynecologist), (gynecologist) and (biochemist).
Last Update: 11/27/2023