The FISH or in-situ hybridization technique allows the chromosomal endowment of spermatozoa to be determined. Most commonly, probes are used to detect alterations in chromosomes 13, 18, 21, X and Y. This complementary technique is especially indicated in patients with implantation failure in previous IVF cycles or repeated miscarriages, but also in men:
- Undergoing oncological treatment of radiotherapy and/or chemotherapy.
- Previous pregnancy with a chromosomal alteration.
- Karyotype alterations.
- Infertility of unknown origin (EOD).
- Advanced paternal age.
Read the full article on: Fluorescent in situ hybridization FISH: Alterations in Sperm Cells ( 82).
By Blanca Paraíso M.D., Ph.D., M.Sc. (gynecologist), Marta Barranquero Gómez B.Sc., M.Sc. (embryologist), Mónica Aura Masip M.D., M.Sc. (gynecologist), Sergio Rogel Cayetano M.D. (gynecologist) and Michelle Lorraine Embleton B.Sc. Ph.D. (biochemist).
Last Update: 11/27/2023
