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Sperm-FISH-Study
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Sperm-FISH-Study

FISH is a cytogenetic technique that allows the DNA of the sperm nucleus to be marked with fluorescent probes to find out if there is any genetic alteration. It is carried out at the interface stage and is usually applied to chromosomes 13, 18, 21, X and Y, as these are the ones that usually present the greatest alterations.

The visualization of the signal produced by the probes is done with a fluorescence microscope. Thus, if a single signal is observed for each chromosome, it corresponds to a normal FISH. On the contrary, the presence of several signals for the same chromosome studied is considered an altered FISH.

By MD, PhD, MSc (gynecologist), BSc, MSc (embryologist) and (invitra staff).
Last Update: 09/11/2019