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Cause of Morris syndrome

Cause of Morris syndrome

Morris syndrome is a genetic alteration linked to the X chromosome that causes a male pseudohermaphroditism, that is, the person has the genotype of a man (XY), but the outward appearance is female.

This is caused by a recessive mutation of the gene that encodes the androgen receptor. People with Morris syndrome have a deficit of these receptors and therefore cannot interact with male sex hormones to perform their function.

Androgens, such as testosterone, are the male hormones produced mainly by the testicles that stimulate the development of male sexual characteristics at puberty. Because people with Morris syndrome are resistant to androgens, their sexual development is characteristic of women.

By (embryologist) and (invitra staff).
Last Update: 04/10/2019