The following are some of the most common causes of secretory or non-obstructive azoospermia:
- Problems in the testes, such as swelling, undescended testicles, infections...
- Chemical exposure, which causes spermatogenic alterations; or cancer treatments, such as chemotherapy, or radiotherapy.
- Genetic disorders, such as azoospermia factor region (AZF) on the Y chromosome
- Hormonal imbalances