Antiphospholipid syndrome (APS) is an autoimmune disease whose diagnosis is made on the basis of clinical and laboratory criteria.
The clinical criterion consists, in general terms, of the presence of thrombosis, recurrent miscarriages, fetal losses or premature deliveries that have not been associated with another cause.
On the other hand, the laboratory criterion is the determination of the presence of antiphospholipid antibodies (APA) by blood test. The main antiphospholipid antibodies studied are lupus anticoagulant, anticardiolipin antibodies and anti-β2glucoprotein I. If any of them give a positive result, the determination should be repeated, at least at 12 weeks, to confirm the result.