It is always difficult to cope with the news of a negative pregnancy test, but it is especially difficult when you have been trying for pregnancy for a long time and undergo a fertility treatment such as in vitro fertilization (IVF). The beginning of menstruation approximately two weeks after the embryo transfer is a severe blow, as it indicates that IVF has not been successful.
However, it is important to know that the probability of achieving a pregnancy on the first IVF attempt is complicated, just as in natural conception. Therefore, IVF patients should not lose hope and keep trying as soon as they are emotionally prepared.
In this article, we will give some advice on how to cope with a negative IVF result and explain some of the possible reasons for this pregnancy test result.
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Pregnancy test result
Once the embryo transfer has been performed, it is necessary to wait at least 12-15 days to perform the pregnancy test. If this pregnancy test is performed early, the likelihood of an abnormal result increases. In particular, a pregnancy test outside of the indicated date could give a false positive or false negative.
In addition, specialists recommend not taking the pregnancy test at home, but waiting for the blood test at the clinic itself to obtain a more reliable result. Blood pregnancy tests provide more accurate results, as they measure the amount of the hormone beta hCG, a hormone that starts to be produced by the embryo itself after implantation in the woman's uterus.
If the beta-hCG test is done at the right time and in the right way, the chances of getting a wrong result are very low. Therefore, if a blood test for the beta hormone hCG gives a negative result, we can confirm that the IVF treatment has not worked and that the woman is not pregnant.
Despite this, it is quite common for the specialist to indicate that the pregnancy test should be repeated after two or three days to confirm IVF failure with greater certainty.
If you want more information about this test, I recommend you check this link: When to Do a Pregnancy Test?
Causes of a negative IVF
When a patient or couple gets a negative pregnancy test result, they may wonder what the reason was. However, there are various reasons as to why IVF has failed. The fertility specialists will be responsible for assessing the possible reason why pregnancy has not been achieved after a round of IVF.
Below, we are going to list some of the medical reasons that could be the cause of a negative IVF:
- An incomplete diagnosis of the infertility cause.
- Low quality of the gametes (eggs and sperm).
- Poor embryonic quality.
- Presence of genetic alterations in the parents.
- Immunological disorders.
- Undetected uterine malformations.
For these reasons, when patients are ready for a new IVF attempt, the medical specialist will make appropriate adjustments to increase success in the next IVF cycle.
Menstruation after a negative IVF
You might ask yourself how long it would take for the menstruation to set in after a confirmed negative IVF.
Generally, the question arises because of the strong desire to try again for pregnancy since the beginning of the menstruation marks the beginning of a new cycle, and thus, the possibility to undergo a new IVF cycle.
If you need to undergo IVF to become a mother, we recommend that you generate your Fertility Report now. In 3 simple steps, it will show you a list of clinics that fit your preferences and meet our strict quality criteria. Moreover, you will receive a report via email with useful tips to visit a fertility clinic for the first time.
Although it is expected that the period sets in after taking the pregnancy test, that is, about two weeks after the transfer, a slight delay is absolutely normal. Medication administered during IVF treatment, both for ovarian stimulation and for endometrial preparation, may cause hormonal imbalances that are responsible for a delayed period.
If menstruation has not set in after two weeks since you last took your medication, it is advisable to ask your fertility doctor in order to check the hormone system and its effect on the ovarian cycle.
It is also possible that the first period after IVF treatment may be more painful or different from the usual menstruation bleedings due to the effects of hormonal drugs and the IVF treatment itself.
Coping with a negative IVF
As we have mentioned, accepting a negative result during in vitro fertilization is not easy, especially from the emotional point of view. Here you have some tips for coping with a negative pregnancy test and regaining strength for a new IVF cycle:
- Don't torture yourself with unanswered questions like: “what did I do?”, “what did I miss?”, “how could it go wrong?”, “what could I have done”? They do not help patients to feel better after a negative IVF and they do not help with the next IVF cycle. These questions only makes you feel sad.
- If necessary, cry. It's good to let off steam and not suppress emotions.
- Performing relaxation exercises such as yoga or mindfulness techniques can be beneficial in calming anxiety, reducing negativity and increasing positive attitude, which is essential to start a new attempt.
- Sharing feelings can help to better assimilate the negative in pregnancy tests
- In case you have decided to inform friends, family and acquaintances that you are in a fertility clinic trying to conceive, it is advisable to make clear that you do not want to answer questions. You will simply report the results when you are ready. This avoids uncomfortable questions and compromising situations.
- Resorting to psychological help in cases where the negative result has caused great distress, anxiety or emotional stress may be necessary and very positive in order to cope.
Psychological help
The vast majority of reproductive centers have fertility psychologists who are willing to help their patients not only to accept fertility problems and the need for assisted reproduction in order to conceive a child but also to offer emotional support throughout the process, including the final pregnancy test.
When this test shows a negative result, there are many feelings that surface, illusions that are broken, and frustration generated. In this respect, having the psychological support of specialists who understand what you are going through and who offer you help tailored to your situation can reduce the distressing situation.
Moreover, this help is also important to face a new reproductive challenge, forgetting the negative outcome of the previous one. Undergoing a new fertility treatment when you have just had a negative experience is not easy. Psychological support in this sense is essential to be able to put all the enthusiasm and effort into the new cycle, as attitude plays an important role in the outcome of a fertility treatment.
FAQs from users
I have finished my first IVF cycle and the result was negative, is it time to move to ICSI or should I try again with IVF?
It depends on the fertilization rate, if it has been correct (≥65%) it would not be strictly necessary. However, today, the ICSI technique is indicated in almost all cycles to avoid total fertilization failures with conventional IVF, which occur in 5-10% of the cases (data from the Spanish Fertility Society Registry - Registro Sociedad Española de Fertilidad, SEF 2016).
What should I do to achieve pregnancy if I'm already going through the third negative IVF?
You should stop, study the possible cause and assess what reproductive treatment is indicated from the results obtained.
Is natural pregnancy possible after negative IVF?
Although it is not common, there have been several cases of couples who, after several unsuccessful IVF attempts, decide to abandon the treatment due to emotional exhaustion and, after some time, achieve a natural pregnancy.
In this sense, emotions and their effects on fertility play a very important role.
After a negative IVF, when can I do the next one?
This depends on each case and the indications given by the doctor. Generally, however, pregnancy can be attempted again in the next cycle, i.e. when the woman's period starts again.
From an emotional point of view, it is recommended to wait until the negative result has been dealt with before starting a new IVF treatment with a positive attitude and enthusiasm.
What is the reason for a negative pregnancy test result after IVF?
There are many possible reasons why IVF may have failed and given rise to a negative pregnancy test result. It may be due to the quality of the gametes (eggs and sperm), the quality of the embryo generated, genetic alterations incompatible with embryonic development, anomalies or malformations in the uterus, immune system problems, etc.
After a negative IVF, a personalised study must be carried out to try to find out the possible cause or causes and optimise the next treatment, with the aim of achieving pregnancy in this new attempt.
What are the symptoms of a negative IVF?
There are no symptoms that indicate that a fertility treatment has not been successful. Specifically, after the embryo transfer until the time of the pregnancy test, some women have a strong urge to urinate, mood swings, headaches, etc.
However, these symptoms are not specific to the implantation of the embryo in the uterus, and therefore to pregnancy.
For this reason, the presence or absence of symptoms during Beta-Wait is not indicative of success or failure, respectively, of an IVF treatment.
Suggested for you
After obtaining a negative result in the first IVF, it is usual to try to achieve a positive result in a second IVF. There are those who throw in the towel after the second or third attempt and those who continue until they achieve pregnancy after the 6th or 7th IVF cycle. But how do you know when it’s enough? We talk about this in the following article: Number of attempts in Assisted Reproduction.
It is also common for us to want to know the reason for the failure in order to do better in the next IVF attempt. Therefore, it is important to know the different factors that influence the success rates of this technique. If you want to know what they are, click on this link: Factors that influence IVF success.
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References
Fanchin R, Harmas A, Benaoudia F, Lundkvist U, Olivennes F, Frydman R. Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome. Fertil Steril. 1998 Nov;70(5):866-70. doi: 10.1016/s0015-0282(98)00277-5.
Gleicher N, A Kushnir V, F Albertini D, H Barad D. Improvements in IVF in women of advanced age. J Endocrinol. 2016 Jul;230(1):F1-6. doi: 10.1530/JOE-16-0105. Epub 2016 May 6.
Miller N, Herzberger E, Pasternak Y, Klement A, Shavit T, Tamir Yaniv R, Ghetler Y, Neumark E, Matzkin Eisenberg M, Berkovitz A, Shulman A, Wiser A. Does stress affect IVF outcomes? A prospective study of physiological and psychological stress in women undergoing IVF. Reprod Biomed Online. 2019 Jul;39(1):93-101. doi: 10.1016/j.rbmo.2019.01.012.
Ricci S, De Giorgi E, Lazzeri E, Luddi A, Rossi S, Piomboni P, De Leo V, Pozzi G. Impact of asymptomatic genital tract infections on in vitro Fertilization (IVF) outcome. PLoS One. 2018 Nov 16;13(11):e0207684. doi: 10.1371/journal.pone.0207684. eCollection 2018.
FAQs from users: 'I have finished my first IVF cycle and the result was negative, is it time to move to ICSI or should I try again with IVF?', 'What should I do to achieve pregnancy if I'm already going through the third negative IVF?', 'Is natural pregnancy possible after negative IVF?', 'After a negative IVF, when can I do the next one?', 'What is the reason for a negative pregnancy test result after IVF?' and 'What are the symptoms of a negative IVF?'.
Hi lovelies!
I’m on my second failed IVF round. The first one was with my eggs and my partner’s sperm. I had a blastocyst transfer and the embryo was of good quality. However, the results came out negative. Later, I had another embryo transfer with a frozen embryo and the result was again negative. I’m so devastated. I don’t understand this. The embryos were good. Everything went fine so far. I just wish for my miracle baby , it this too much to ask. Life is unfair. Others pop out 4 kids in a row and I can’t even have one.
Hi there,
I just went through my first IVF. However, it was negative. Results that my eggs are not sufficient and we are planning on getting egg donation IVF.
Can someone share their experience? What are the pros & cons of IVF with donated eggs?
Hi Anne,
First of all, I am very sorry that your test was negative. However, don’t let it mess with you, as a positive attitude is essential in fertility treatments. I understand that it is complicated, but you must stay strong.
When the ovarian reserve is low or the eggs are of poor quality, it is best to resort to IVF with egg donation. This reproductive option has a high success rate, since the eggs used are of good quality because they come from young, healthy women.
However, egg donation is a fairly expensive fertility treatment due to the cost of medication for ovarian stimulation of the donor and financial compensation for the inconvenience caused. In addition, IVF with donor eggs means giving up the genetic load.
I recommend that you visit the following article for more detailed information about this fertility treatment: Donor-Egg IVF Procedure for Recipients – Protocol & Cost
Hope this helps,
wish you all the best.
I wanna share my story here. Maybe there are like-minded peeps.
I’m 34 years old, I’ve been trying to conceive for three years, I had two normal pregnancies that ended in miscarriage. Then I had my first IVF that was negative. The second one was positive, which, however, ended in a miscarriage again. We changed the fertility clinic and they suggested PGD. Results that our embryos have chromosomal problems that might have caused miscarriage. We will try with egg donation IVF now since my eggs are not good enough.