By Neus Ferrando Gilabert BSc, MSc (embryologist).
Last Update: 05/06/2014

Human menopausal gonadotropin or menotropin is prescribed for ovulation induction in assisted reproductive treatments, such as artificial insemination, conventional IVF, or ICSI.

Menotropin is extracted from the urine of menopausal women, hence its name. It contains 75 IU FSH (follicle-stimulating hormone) and 75 IU LH (luteinizing hormone) – IU stands for international units and is a unit of measurement for biological activity.

Follicles being stimulated

Indications

It is used to stimulate the ovarian function: it produces a higher recruitment of the follicles, as well as their development.

The hMG is indicated for women that are going to undergo an assisted reproduction treatment. It’s administered through injections in order to obtain a higher ovarian stimulation during one cycle. When we talk about hMG we are actually referring to a compound where we can find two hormones in the same concentration (50%), FSH and LH.

Advantages and disadvantages

The administration of hormones in order to achieve a higher number and development of the ovarian follicles is quite common and can be applied safely, as long as the treatment is under the supervision of an expert.

Use hMG

The main advantage is the development of a larger number of follicles.

The disadvantages that must be taken into account are the possibility of producing:

  • Ovarian hyperstimulation syndrome (OHSS): in artificial insemination, it presents a minor risk and can be easily solved by cancelling the insemination cycle.
  • Multiple births: in artificial insemination occurs among 12-30% of cases, being more common among young women with more than 5 ovarian follicles larger than 16 mm and inseminated with more than 30 million spermatozoa. As for in vitro fertilisation, if two embryos are transferred, the probability of twin pregnancy is 6%. In cycles where three embryos are transferred, the probability of twin pregnancy is 12% and that of triplet pregnancy is 3%.

Allergic reactions to hMG rarely occur, that’s why its administration is not considered a risk.

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Authors and contributors

 Neus Ferrando Gilabert
BSc, MSc
Embryologist
Bachelor's Degree in Biology from the University of Valencia (UV). Postgraduate Course in Biotechnology of Human Assisted Reproduction from the Miguel Hernández University of Elche (UMH). Experience managing Embryology and Andrology Labs at Centro Médico Manzanera (Logroño, Spain). More information
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