What Are the Advantages of Intrauterine Insemination?

By (embryologist), (gynecologist), (embryologist), (gynecologist) and (psychologist).
Last Update: 01/12/2022

Like all other assisted reproductive techniques, artificial insemination (AI) has certain advantages and also some disadvantages.

AI is considered a low-complexity technique, so its main advantage is that it is a simple and minimally invasiveprocedure.

However, certain requirements are needed to achieve pregnancy by AI and the results are worse compared to in vitro fertilization (IVF).

Advantages of artificial insemination

Although there are several types of AI depending on the site where the sperm are deposited, the most common is intrauterine artificial insemination and, for this reason, is the one we refer to when we speak simply of AI.

The process of intrauterine artificial insemination is very simple and consists of introducing the sperm directly into the woman's uterus, through the cervix, with the help of a cannula.

The semen sample for AI is preprocessed in the laboratory and can come from the couple (conjugal AI, homologous AI, or CAI) or from a sperm donor (heterologous AI or DAI).

The following are the main benefits or advantages of artificial insemination.

Similarity with natural conception

AI is the assisted reproductive technique that most closely resembles natural conception. Unlike IVF cycles (where the patient's eggs are extracted by follicular puncture and subsequently fertilized in the laboratory), in AI fertilization occurs inside the woman's body.

Furthermore, although it is true that in AI the sperm is artificially introduced into the patient's uterus to facilitate their journey, there is a natural selection in the female reproductive tract of the sperm that will eventually fertilize the egg.

Simplicity and low cost

AI can be performed in the gynecologist's office itself, without the need to go to the operating room. It is a very simple, fast and comfortable technique for the patient.

The process of introducing the cannula through the cervix to perform AI is painless and does not require anesthesia.

On the other hand, the ovarian stimulation performed prior to AI is milder than that required for IVF treatment, since only 1-2 follicles are sought for maturation. This reduces the side effects, the risks caused by hormone treatment and the costs associated with this medication.

In addition, because AI does not require too much personnel intervention, nor an operating room, nor embryo culture with complex maintenance and handling systems, its cost is lower than that of IVF treatments.

Advantages derived from the technique itself

In addition to the benefits discussed above, AI also has advantages that are characteristic of the insemination process itself:

  • It increases the chances of gestation compared to natural conception due to the slight ovarian stimulation, the control to perform the insemination close to the ovulatory period, the processing of the semen sample and the introduction of the sperm directly into the uterus.
  • It allows single women and couples formed by two women to become mothers through sperm donation.

Assisted procreation, as any other medical treatment, requires that you rely on the professionalism of the doctors and staff of the clinic you choose. Obviously, each clinic is different. Get now your Fertility Report, which will select several clinics for you out of the pool of clinics that meet our strict quality criteria. Moreover, it will offer you a comparison between the fees and conditions each clinic offers in order for you to make a well informed choice.

For all these reasons, AI is a widely used technique and should be the first choice for assisted reproduction in couples who do not have any factors that make it inadvisable.

Disadvantages of artificial insemination

Even with all the advantages mentioned above, the simplicity of the AI procedure implies certain requirements on the couple and influences the success rates. In addition, AI may have certain risks.

Requirements

AI is not an appropriate technique for all women or couples attending a fertility clinic. The specialist will be the one to assess and explain to the couple which assisted reproduction treatment may be the most appropriate in their case.

In order to achieve a pregnancy with the AI technique, the following conditions are required in the couple:

  • The woman's fallopian tubes must be functional, as this is where fertilization will occur.
  • The woman must not have any problems that prevent her from ovulating spontaneously or induced by hormonal medication
  • The quality of the spermatozoa must be good and present favorable results, or only slight alterations, in the semen analysis. In addition, a REM (motile sperm count) greater than 3 million progressive motile sperm is recommended after processing of the semen sample.

On the other hand, AI is usually used in young women with a maximum age of 35-37 years to have an acceptable chance of success.

Success rate

AI requires less human intervention than IVF. This also results in significantly lower success rates.

In the latest National Activity Registry of the Spanish Fertility Society (SEF) for 2019, the gestation rate (per cycle) for AI stands at 16% in women under 35 years of age. However, the delivery rate (per cycle) is 13% for women of the same age group.

For this reason, several AIs are usually performed to achieve gestation. It is usual to make 4 attempts with AI before opting for another assisted reproductive technique. Thus, the cumulative pregnancy rate amounts to approximately 60%. After the fourth AI attempt, the cumulative rate does not increase, so it is not advisable to continue seeking pregnancy by this technique.

If you wish to obtain more detailed information on the subject, we recommend you to visit the following article: What is the probability of success of artificial insemination?

Risks

Despite its simplicity, AI is not without certain risks, such as those mentioned below:

  • Ovarian hyperstimulation syndrome (OHSS). This syndrome is not very frequent in AI, since ovarian stimulation is mild.
  • Multiple pregnancy, due to the maturation of more than 1 egg after ovarian stimulation. Multiple gestations are associated with increased obstetric risk during pregnancy and delivery.
  • Ectopic pregnancy
  • Infections or allergic reactions. Although very infrequent, such problems can occur after AI.

You can read more about these AI risks by clicking on the following link: Risks and consequences of artificial insemination.

FAQs from users

What are the advantages of donor AI over spousal AI?

By Mónica Aura Masip M.D., M.Sc. (gynecologist).

Conjugal insemination (CAI) is indicated when there is a mild fertility problem, either due to an ovulatory factor, mild endometriosis, mild male factor or idiopathic cause. Within the mild male causes, there may be a mild decrease in sperm concentration or motility, but most of the time there is already a cause of infertility.

In the case of inseminations with donor sperm, we use a totally normal sperm (donor) and with a good fertilizing capacity and, generally, there are no fertility problems in the woman. There may be cases of single women, couples of women or severe male factors such as secretory azoospermia that require a male gamete change. This means that the reproductive prognosis or the possibilities of success are slightly higher with donor sperm.

On the other hand, the use of donor sperm allows us to have a little more security due to the numerous medical, analytical and genetic tests that are performed on donors in order to avoid the birth of a sick child or the transmission of any genetic or infectious disease.

What are the advantages of AI ovarian stimulation over IVF?

By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).

The advantages of ovarian stimulation prior to AI, compared to that performed before IVF, are:

  • Fewer side effects associated with hormonal treatment.
  • Less risk of ovarian hyperstimulation syndrome (OHSS).
  • Less cost associated with medication.

All these advantages are related to the lower amount of gonadotropins required in AI, since only 1-2 follicles are being matured.

Is it inconvenient to have a tubal ligation to perform an AI?

By Silvia Azaña Gutiérrez B.Sc., M.Sc. (embryologist).

Yes, in order to perform an artificial insemination, it is necessary that the fallopian tubes are functional. Having the tubes tied will prevent the egg and sperm from meeting and, therefore, fertilization will not be possible.

However, in vitro fertilization (IVF) treatments do not have this requirement, since fertilization takes place outside the woman's body, that is, in the laboratory.

If you want to continue reading more in-depth about the process of artificial insemination, you can visit the following link: How is artificial insemination done step by step?

If what you need is information about IVF treatments, we recommend you to read this article: In vitro fertilization (IVF): What is it and how much does it cost?

We make a great effort to provide you with the highest quality information.

🙏 Please share this article if you liked it. 💜💜 You help us continue!

References

Cohlen B, Bijkerk A, Van der Poel S, Ombelet W. IUI: review and systematic assessment of the evidence that supports global recommendations. Hum Reprod Update. 2018 May 1;24(3):300-319.

Ejzenberg D, Gomes TJO, Monteleone PAA, Serafini PC, Soares-Jr JM, Baracat EC. Prognostic factors for pregnancy after intrauterine insemination. Int J Gynaecol Obstet. 2019 Oct;147(1):65-72.

Evans MB, Stentz NC, Richter KS, Schexnayder B, Connell M, Healy MW, Devine K, Widra E, Stillman R, DeCherney AH, Hill MJ. Mature Follicle Count and Multiple Gestation Risk Based on Patient Age in Intrauterine Insemination Cycles With Ovarian Stimulation. Obstet Gynecol. 2020 May;135(5):1005-1014.

Matorras R, Rubio K, Iglesias M, Vara I, Expósito A. Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review. Reprod Biomed Online. 2018 Feb;36(2):164-171.

Sociedad Española de Fertilidad. Registro Nacional de Actividad 2019-Registro SEF (see)

FAQs from users: 'What are the advantages of donor AI over spousal AI?', 'What are the advantages of AI ovarian stimulation over IVF?' and 'Is it inconvenient to have a tubal ligation to perform an AI?'.

Read more

Authors and contributors

 Andrea Rodrigo
Andrea Rodrigo
B.Sc., M.Sc.
Embryologist
Bachelor's Degree in Biotechnology from the Polytechnic University of Valencia. Master's Degree in Biotechnology of Human Assisted Reproduction from the University of Valencia along with the Valencian Infertility Institute (IVI). Postgraduate course in Medical Genetics. More information about Andrea Rodrigo
 Mónica  Aura Masip
Mónica Aura Masip
M.D., M.Sc.
Gynecologist
Dr. Mónica Aura has a degree in Medicine and General Surgery from the Autonomous University of Barcelona (UAB). She is also a specialist in Gynecology and Obstetrics from the Hospital de Santa Creu y Sant Pau and has a Master's degree in Human Assisted Reproduction from the University Juan Carlos I of Madrid and another in Health Center Management from the UB. More information about Mónica Aura Masip
Licence number: 31588
 Silvia Azaña Gutiérrez
Silvia Azaña Gutiérrez
B.Sc., M.Sc.
Embryologist
Graduate in Health Biology from the University of Alcalá and specialized in Clinical Genetics from the same university. Master in Assisted Reproduction by the University of Valencia in collaboration with IVI clinics. More information about Silvia Azaña Gutiérrez
License: 3435-CV
 Valeria Sotelo
Valeria Sotelo
M.D., M.Sc.
Gynecologist
Bachelor's Degree in Medicine from the University of Buenos Aires. Specialist in Gynecology & Obstetrics. Master's Degree in Video-laparoscopic Surgery, and Certificate of Specialist in Gynecology. Associate Member of the Spanish Fertility Society (SEF) and the Spanish Society of Gynecology & Obstetrics. More than 10 years of experience in the field of Reproductive Medicine. More information about Valeria Sotelo
License: 030309166
Adapted into english by:
 Cristina  Algarra Goosman
Cristina Algarra Goosman
B.Sc., M.Sc.
Psychologist
Graduated in Psychology by the University of Valencia (UV) and specialized in Clinical Psychology by the European University Center and specific training in Infertility: Legal, Medical and Psychosocial Aspects by University of Valencia (UV) and ADEIT.
More information about Cristina Algarra Goosman
Member number: CV16874

Find the latest news on assisted reproduction in our channels.