What differences exist between artificial insemination and IVF?

By (gynecologist), (reproductive endocrinologist), (gynecologist), (embryologist), (gynecologist), (gynecologist), (embryologist) and (biochemist).
Last Update: 11/07/2023

There are several types of fertility treatments and assisted reproductive techniques that can help infertile men and women achieve pregnancy and fulfill their dream of parenthood.

The most widely used treatments, and therefore the best known in today's society, are artificial insemination (AI) and in vitro fertilization (IVF).

Each of these techniques is indicated for different patients and different fertility problems. Therefore, it is very important to be familiar with them and to know which treatment is the most appropriate to ensure success.

Provided below is an index with the 6 points we are going to expand on in this article.

Choosing your fertility treatment

All couples who do not achieve pregnancy after one year of unprotected sex should start to see a fertility clinic to have their infertility tested.

The recommended waiting time is reduced to 6 months in women over 36 years. Neither will it be necessary to wait if there are obvious problems of sterility.

Once the results of the fertility tests have been obtained, which include hormone analysis, ultrasound and semen analysis, the specialist assesses which technique is the most suitable for each case. Some of the aspects that are taken into account are the following:

The specialist will have to explain all this information to its patients and the reasons why one or another technique is recommended such as the procedures, risks, success rates, etc and so on.

However, ìt is the patients themselves who have to accept whether to do an artificial insemination or in vitro fertilization, and sign the appropriate consent forms to start the treatment.

Differences between insemination and IVF

AI is a simpler technique than IVF and, therefore, is the first treatment indicated on many occasions. This reproductive option consists of depositing capacitated sperm, previously obtained in the laboratory, inside the woman's uterus. For this purpose, the patient is subjected to a slight ovarian stimulation.

The sperm swim into the fallopian tubes (where the egg will be) and fertilization takes place naturally. For this, it is necessary for the woman to have permeable fallopian tubes and for the man to have good seminal quality.

On the other hand, IVF is a more complicated technique. After controlled ovarian stimulation, the woman's eggs are removed through a surgical procedure known as follicular puncture.

The retrieved eggs are fertilized in the laboratory with the couple's or a donor's sperm, and then the best quality embryo or embryos are transferred to the woman's uterus for pregnancy to take place.

When to do AI and when IVF?

Artificial insemination is usually indicated when infertility problems are minimal or as a first strategy in the face of sterility of unknown origin.

As we have said, it is necessary to meet certain prerequisites and, therefore, its indications are as follows:

  • It is advisable for women under 35-37 years of age.
  • Ovulation alterations or ovarian reserve alterations should be minimal.
  • Patients must present tubal patency and no evidence of severe male fertility problems.
  • As for the male partner, his semen sample must reach the minimum values, with a Motile Sperm Concentration (MSC) of at least 3 million sperm.

When infertility problems are more severe or the woman is older than 37, the most appropriate treatment is IVF. Below, we will comment on its most frequent indications:

In the most severe cases, it will be necessary to use the ICSI technique (intracytoplasmic sperm injection) to fertilize the eggs during an IVF. If you want to know the indications for this particular technique, you can read more here: When Is ICSI Recommended?

Medication for ovarian stimulation

In both AI and IVF, it is necessary to administer hormonal medication to the woman so that controlled follicular development takes place.

In the case of AI, the dose of gonadotropins (FSH and LH) will be much lower than in IVF, since the aim is to achieve only one or two mature follicles for insemination. If a greater follicular development were obtained, there would be a risk of multiple pregnancies.

In in vitro fertilization, on the other hand, ovarian stimulation is greater to achieve a multiple follicular development which results in the production of a high number of eggs and thus increases the possibility of obtaining good embryos.

It is normal to obtain between 6-10 eggs per IVF cycle. After fertilization and embryo transfer, the remaining embryos are vitrified for use in future attempts or to have a second child.

Whether you need to undergo IUI or IVF to become a mother, we recommend that you get your Fertility Report now. In 3 simple steps, it will show you a list of clinics that fit your preferences and meet our strict quality criteria. Moreover, you will receive a report via email with useful tips to visit a fertility clinic for the first time.


The cost of a fertility treatment might vary from clinic to clinic. However, whatever the final cost is, there is a significant difference between the cost of artificial insemination and in vitro fertilization.

The cost of artificial insemination may range from $400 to $4,000, whereas in vitro fertilization can reach $12,000 and even $14,000, as it includes surgery, egg fertilization in the laboratory and the subsequent embryo transfer. Given that the entire process requires more involvement of the specialist, it implies a higher overall cost.

Even though fertility medication is not usually included in the overall cost by default, patients are advised to add the cost of medications, as it may vary greatly. For intrauterine insemination, ovulation induction drugs may cost from $600 to $1,000, while in the case of in vitro fertilization it is around $2,000- $6,000.

Related topic: Overview of the Main Costs of Fertility Treatments.

Success rates

Success rates also vary significantly between AI and IVF.

Obviously, with IVF there is a greater chance of achieving pregnancy because the 3 or 5-day old embryo already developed is introduced into the uterus. The only thing that has to occur naturally in the woman is implantation.

Next, we are going to comment on the birth rates achieved in both techniques depending on the age of the woman, according to the latest data published by the Spanish Fertility Society (SEF) for the year 2021.

Women under <35 years old
the birth rate for IUI is 14.7%, whereas the birth rate per transfer in IVF-ICSI is 34.6%.
Women between 35 - 39 years
the birth rate for IUI is 11.7%, whereas the birth rate per transfer in IVF-ICSI is 25.3%.
Women ≥40 years old
the birth rate for IUI is 5.1%, whereas the birth rate per transfer in IVF-ICSI is 12.8%.

As you can see from the figures, age is a very important factor when deciding on an assisted reproduction technique. However, these values also depend to a great extent on the cause of sterility.

In conclusion, there is no one technique that is better than the other. Each treatment must be adapted to each type of patient and all the procedures must be personalized as much as possible to increase success rates as much as possible.

FAQs from users

Does it help IVF if artificial insemination attempts have been previously performed?

By Marta Zermiani M.D., Ph.D. (gynecologist).

With Artificial Insemination, success rates of up to 30% (depending on the age of the patient) can be achieved after 3-4 attempts. If pregnancy is not achieved after these attempts, we usually propose a more complex treatment such as in vitro fertilization (IVF).

The fact of having carried out an ovarian stimulation treatment prior to artificial insemination allows us to see how the ovary responds to the medication, even if it is at much lower doses. It also allows us to know how the endometrium is developing and if there are any problems at that level.

We definitely start the cycle with more information than if we had not performed any previous stimulation, although the techniques are usually very different in terms of doses of hormonal medication, the objective with IVF being to recruit a large number of follicles, while with artificial insemination, the maximum is 2.

Does artificial insemination involve the same risks as in vitro fertilization?

By Mark P. Trolice M.D., F.A.C.O.G., F.A.C.S., F.A.C.E. (reproductive endocrinologist).

All fertility treatment cycles involving ovarian stimulating medication have similar risks but the difference is the degree of severity. For cycles using only oral or injectable fertility medications, the risks of an ectopic pregnancy, ovarian hyperstimulation syndrome and ovarian torsion are less than 5% in both IUI and IVF cycles.

The difference between IUI and IVF are the pregnancy success rates and risk of multiple births. In an IUI cycle using oral medication, the risk of a multiple pregnancy is less than 5% but increase to 10-15% when injectable fertility medications are used.

The unique distinction of IVF is the ultrasound guided vaginal egg retrieval and the ability to transfer a predetermined number of embryos. As a result, the risks with an egg retrieval included intra-abdominal bleeding, injury to the bowel and bladder, and infection. Fortunately, all of complications occur in less than 1% of cycles. Further, the risk of a multiple pregnancy is directly related to the number of embryos transferred: a single embryo transfer has a 1% risk of dividing into a twin pregnancy; a double embryo transfer can increase the risk of a twin pregnancy in up to 40% of cycles.

Is the success rate higher in AI or IVF?

By Miguel Angel Checa Vizcaino M.D., Ph.D. (gynecologist).

Undoubtedly, in vitro fertilization (IVF) has higher gestation rates than artificial insemination. In fact, artificial insemination is not recommended after 37 years of age.

At present, AI should be reserved for very young women (<35 years) and with less than two years of infertility, for women without a male partner or in homosexual families.

Is AI or IVF more effective?

By Dra. María Calomarde Rees M.D. (gynecologist).

Because it is a more controlled treatment, IVF is much more effective than AI. Thanks to IVF, we can observe the quality of the oocytes, the evolution of the embryos and select the best embryo for transfer.

IVF makes it possible to detect failures in fertilization or during embryo development and to better diagnose cases of infertility. On the other hand, if the result of an AI is negative, we will not know if the fertilization was performed correctly, since it occurs in the woman's body.

To achieve greater effectiveness of IVF, we can use the technique of Preimplantational Genetic Diagnosis, which will help in the selection of embryos according to their genetics.

How many IUI cycles should you do before moving on to IVF?

By Óscar Oviedo Moreno M.D. (gynecologist).

In couples with a good prognosis, that is, under the age of 37, with a normal sperm sample, we recommend 4 IUI attempts before moving on to IVF. In the case of single women or donor insemination cycles, up to 6 attempts are recommended. It depends on the clinical history of each patient, though.

Which technique is best for single women or lesbian couples trying to get pregnant - IUI or IVF?

By Zaira Salvador B.Sc., M.Sc. (embryologist).

All those women without a male partner who wish to become mothers will be able to fulfill their dream thanks to sperm donation. In general, if the woman being treated does not present any infertility problems, artificial insemination with donor sperm (AID) is the best option. On the other hand, if the woman is over 36 years old and her ovarian reserve is affected, she will have to resort to IVF with a sperm donor.

Are in vitro fertilization and artificial insemination the same thing?

By Marta Barranquero Gómez B.Sc., M.Sc. (embryologist).

The answer is no. These are two different assisted reproduction treatments.

In vitro fertilization (IVF) is a highly complex technique characterized by the fact that fertilization takes place in the laboratory. The eggs are extracted from the woman by ovarian puncture and fertilized with the sperm of the male partner or a donor. The best quality embryos generated in the laboratory are transferred to the woman's uterus so that they can implant and give rise to a pregnancy.

Artificial insemination (AI), on the other hand, is a low complexity reproductive treatment. In this case, the semen sample, previously capacitated, is introduced into the woman's body. Therefore, fertilization occurs inside the woman's body in AI.

If you want to learn about artificial insemination in more detail, you can continue your reading with this article: What Is Artificial Insemination (AI)? - Process, Cost & Types

Alternatively, if you are interested in the treatment of IVF, you can find more information in this article: What Is In Vitro Fertilization (IVF)? - Process, Cost & Success Rates

We make a great effort to provide you with the highest quality information.

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Goldberg JM, Mascha E, Falcone T, Attaran M (1999). Comparison of intrauterine and intracervical insemination with frozen donor sperm: a meta-analysis. Fertil Steril; 72(5):792-5 (View)

Gomez-Polomares JL, Juliia B, Acevedo-Martin B, Martinez-Burgos M, Hernandez ER, Ricciarelli E (2005). Timing ovulation for intrauterine insemination with a GnRH antagonist. Hum Reprod;20:368 – 372 (View)

The ESHRE Capri Workshop Group (2009). Intrauterine insemination. Human Reproduction Update; 15 (3): 265–277.64 (View)

Sociedad Española de Fertilidad. Registro Nacional de Actividad 2021-Registro SEF (View)

FAQs from users: 'Does it help IVF if artificial insemination attempts have been previously performed?', 'Does artificial insemination involve the same risks as in vitro fertilization?', 'Is the success rate higher in AI or IVF?', 'Is AI or IVF more effective?', 'How many IUI cycles should you do before moving on to IVF?', 'Which technique is best for single women or lesbian couples trying to get pregnant - IUI or IVF?' and 'Are in vitro fertilization and artificial insemination the same thing?'.

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Authors and contributors

Dra. María Calomarde Rees
Dra. María Calomarde Rees
Dr. María Calomarde has a degree in Medicine and Surgery from the University of Valencia and specialized in Gynecology and Obstetrics at the Hospital Universitario La Paz, Madrid. She also has a Diploma in Advanced Studies (DEA) and Research Sufficiency from the Department of Gynecology and Obstetrics of the Autonomous University of Madrid. More information about Dra. María Calomarde Rees
Member number: 282863855
 Mark P. Trolice
Mark P. Trolice
M.D., F.A.C.O.G., F.A.C.S., F.A.C.E.
Reproductive Endocrinologist
Mark P. Trolice is the Director of Fertility CARE – The IVF Center and Clinical Associate Professor in the Department of Obstetrics & Gynecology (OB/GYN) at the University of Central Florida College of Medicine. He is Board-certified in REI and OB/GYN, and maintains annual recertification. His colleagues select him as Top Doctor in America® annually, one among the top 5% of doctors in the U.S. More information about Mark P. Trolice
License: ME 78893
 Marta Zermiani
Marta Zermiani
M.D., Ph.D.
Graduated in Medicine and Surgery from the Università degli Studi di Padova in Italy, specializing in Gynecology and Obstetrics at the Hospital Universitario de Bellvitge in Barcelona. Specialist in Assisted Reproduction with 4 years experience and currently a gynecologist at Vida Fertility Madrid. More information about Marta Zermiani
Licence number: 280847526
 Marta Barranquero Gómez
Marta Barranquero Gómez
B.Sc., M.Sc.
Graduated in Biochemistry and Biomedical Sciences by the University of Valencia (UV) and specialized in Assisted Reproduction by the University of Alcalá de Henares (UAH) in collaboration with Ginefiv and in Clinical Genetics by the University of Alcalá de Henares (UAH). More information about Marta Barranquero Gómez
License: 3316-CV
 Miguel Angel Checa Vizcaino
Miguel Angel Checa Vizcaino
M.D., Ph.D.
Dr. Miguel Angel Checa has a degree in Medicine and Surgery and a doctorate in Pediatrics, Obstetrics and Gynecology, Preventive Medicine and Public Health from the Autonomous University of Barcelona. More information about Miguel Angel Checa Vizcaino
Zulassungsnummer: 080830513
 Óscar Oviedo Moreno
Óscar Oviedo Moreno
Bachelor's Degree in Medicine & Surgery from the University of Caldas (Colombia). Specialist in Internal Medicine by the Pontificia Universidad Javeriana of Bogotá. Degree standardized in Spain in 2003. Specialist in Gynecology & Obstetrics from the Complutense University of Madrid, with residence at Hospital Clínico Universitario San Carlos de Madrid. Expert in Reproductive Medicine and Certification in Obstetric-Gynecologic Ultrasound (levels I, II and III). More information about Óscar Oviedo Moreno
License: 282858310
 Zaira Salvador
Zaira Salvador
B.Sc., M.Sc.
Bachelor's Degree in Biotechnology from the Technical University of Valencia (UPV). Biotechnology Degree from the National University of Ireland en Galway (NUIG) and embryologist specializing in Assisted Reproduction, with a Master's Degree in Biotechnology of Human Reproduction from the University of Valencia (UV) and the Valencian Infertility Institute (IVI) More information about Zaira Salvador
License: 3185-CV
Adapted into english by:
 Michelle Lorraine Embleton
Michelle Lorraine Embleton
B.Sc. Ph.D.
PhD in Biochemistry, University of Bristol, UK, specialising in DNA : protein intereactions. BSc honours degree in Molecular Biology, Univerisity of Bristol. Translation and editing of scientific and medical literature.
More information about Michelle Lorraine Embleton

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